Table 3 Micronucleus assay of POM93 in vivo
From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
Treatment | Dose (mg/kg b.w.) | Number of animals observed | Number of cells observed | Frequency of micronucleated polychromatic erythrocyte (‰) | Ratio of polychromatic erythrocyte (PCE) to total erythrocytes (%) |
|---|---|---|---|---|---|
Positive control Cyclophosphamide | 200 | 5 | 10,000 | 32.70 ± 3.16* | 1.20 ± 0.14 |
POM93 | 625 | 5 | 10,000 | 5.00 ± 1.56 | 0.70 ± 0.31 |
1250 | 5 | 10,000 | 3.50 ± 1.08 | 0.89 ± 0.27 | |
2500 | 5 | 10,000 | 5.70 ± 1.49 | 0.73 ± 0.22 | |
Negative control | 0 | 5 | 10,000 | 5.40 ± 1.51 | 0.55 ± 0.15 |