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Table 3 Micronucleus assay of POM93 in vivo

From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Treatment Dose (mg/kg b.w.) Number of animals observed Number of cells observed Frequency of micronucleated polychromatic erythrocyte (‰) Ratio of polychromatic erythrocyte (PCE) to total erythrocytes (%)
Positive control Cyclophosphamide 200 5 10,000 32.70 ± 3.16* 1.20 ± 0.14
POM93 625 5 10,000 5.00 ± 1.56 0.70 ± 0.31
  1250 5 10,000 3.50 ± 1.08 0.89 ± 0.27
  2500 5 10,000 5.70 ± 1.49 0.73 ± 0.22
Negative control 0 5 10,000 5.40 ± 1.51 0.55 ± 0.15
  1. Both the ratios of polychromatic erythrocyte (PCE) to total erythrocytes (%) and the frequency of micronucleated polychromatic erythrocyte (‰) in treated group were not statistically different from those of the negative control animals, suggesting that the treatment with POM93 did not cause erythropoietic cell toxicity and genotoxicity in vivo. Data are expressed as mean ± S.D. (n = 6). Statistical analysis: *P < 0.05 indicate a statistical difference with the control group by one-way ANOVA