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Table 4 Effect of the subchronic 13-week oral administration of POM93 on hematological parameters in Wistar rats

From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Time (d) Hematological parameters POM93 (mg/kg)
Control water 62.2 195.7 587.0
90 WBC (× 109/L) 14.20 ± 5.07 9.40 ± 2.91 12.20 ± 3.52 13.44 ± 4.33
RBC (× 1012/L) 9.11 ± 0.77 8.28 ± 1.16 8.67 ± 0.73 8.79 ± 1.91
PLT (× 109/L) 657.40 ± 402.57 334.20 ± 296.94 356.40 ± 247.47 536.56 ± 338.81
HB (g/L) 149.60 ± 11.88 142.50 ± 19.42 147.50 ± 15.36 144.67 ± 20.43
105 WBC (× 109/L) 15.36 ± 3.45 15.52 ± 4.18 16.90 ± 12.35 24.20 ± 10.20
RBC (× 1012/L) 8.96 ± 1.00 8.77 ± 0.91 8.72 ± 0.90 8.44 ± 0.81
PLT (× 109/L) 500.56 ± 185.23 490.90 ± 260.25 519.90 ± 343.95 587.67 ± 366.49
HB (g/L) 149.56 ± 13.91 152.20 ± 12.93 143.90 ± 12.41 135.17 ± 16.38
  1. Hematology profiles were within the normal range and unaffected by the POM93 treatment. Data are expressed as mean ± S.D. (n = 20)