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Table 5 Effect of the subchronic 13-week oral administration of POM93 on biochemical parameters in Wistar rats

From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Time (d) Biochemical parameters POM93 (mg/kg)
Control water 62.2 195.7 587.0
90 ALT (U/L) 108.40 ± 13.78 121.30 ± 14.85 112.40 ± 14.26 119.90 ± 10.83
AST (U/L) 154.50 ± 20.66 192.90 ± 22.24* 169.40 ± 28.56 197.60 ± 46.37*
ALP (U/L) 136.60 ± 12.90 129.80 ± 48.60 106.70 ± 24.87 121.10 ± 29.89
T-B IL (mmol/L) 0.32 ± 0.15 0.34 ± 0.22 0.44 ± 0.29 0.51 ± 0.25
D-B IL (mmol/L) 0.68 ± 0.30 0.88 ± 0.56 0.85 ± 0.51 0.74 ± 0.45
TP (mmol/L) 75.80 ± 3.92 78.55 ± 5.90 80.55 ± 7.64 82.10 ± 8.14
UREA (mmol/L) 7.90 ± 1.65 8.81 ± 1.08 9.97 ± 2.19* 10.23 ± 0.65
CREA (mmol/L) 54.20 ± 8.09 52.80 ± 8.69 56.80 ± 7.34 79.70 ± 13.32*
CHOL (mmol/L) 1.64 ± 0.15 1.53 ± 0.33 1.62 ± 0.40 1.67 ± 0.33
TG (mmol/L) 0.98 ± 0.11 1.07 ± 0.17 0.90 ± 0.13 1.10 ± 0.25
GLU (mmol/L) 1.87 ± 0.13 1.89 ± 0.29 1.70 ± 0.35 1.78 ± 0.30
105 ALT (U/L) 132.90 ± 20.10 158.60 ± 17.18* 159.90 ± 19.11* 162.30 ± 8.16*
AST (U/L) 165.40 ± 15.05 200.20 ± 21.69* 200.00 ± 16.95* 242.30 ± 32.88*
ALP (U/L) 141.60 ± 23.16 195.80 ± 63.17 197.40 ± 83.28 240.0 ± 165.90
T-B IL (mmol/L) 0.51 ± 0.30 0.39 ± 0.33 0.52 ± 0.28 0.75 ± 0.43
D-B IL (mmol/L) 0.76 ± 0.21 1.17 ± 0.76 0.93 ± 0.38 0.85 ± 0.49
TP (mmol/L) 76.57 ± 6.51 80.51 ± 3.44 79.41 ± 4.55 80.03 ± 9.74
UREA (mmol/L) 7.32 ± 1.32 8.00 ± 1.80 8.26 ± 2.04 10.63 ± 1.14*
CREA (mmol/L) 40.10 ± 3.25 48.80 ± 6.97* 51.30 ± 7.54* 62.60 ± 3.77*
CHOL (mmol/L) 1.35 ± 0.19 1.52 ± 0.32 1.61 ± 0.24 1.49 ± 0.60
TG (mmol/L) 1.13 ± 0.26 0.85 ± 0.30 1.04 ± 0.33 1.03 ± 0.46
  GLU (mmol/L) 4.26 ± 0.84 4.21 ± 0.65 3.91 ± 0.51 4.48 ± 0.73
  1. Most serum biochemical parameters were within the normal range, except the pharmacological effects ALT in 90 d treated groups, AST, UREA, and CREA in 90 and 105 days treated groups, after a 13-week POM93 oral treatment. The results are shown as average ± S.D. (n = 20), *P < 0.05 versus control and P < 0.05 versus 62.2 mg/kg groups by one-way ANOVA