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Table 5 Effect of the subchronic 13-week oral administration of POM93 on biochemical parameters in Wistar rats

From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Time (d)

Biochemical parameters

POM93 (mg/kg)

Control water

62.2

195.7

587.0

90

ALT (U/L)

108.40 ± 13.78

121.30 ± 14.85

112.40 ± 14.26

119.90 ± 10.83

AST (U/L)

154.50 ± 20.66

192.90 ± 22.24*

169.40 ± 28.56

197.60 ± 46.37*

ALP (U/L)

136.60 ± 12.90

129.80 ± 48.60

106.70 ± 24.87

121.10 ± 29.89

T-B IL (mmol/L)

0.32 ± 0.15

0.34 ± 0.22

0.44 ± 0.29

0.51 ± 0.25

D-B IL (mmol/L)

0.68 ± 0.30

0.88 ± 0.56

0.85 ± 0.51

0.74 ± 0.45

TP (mmol/L)

75.80 ± 3.92

78.55 ± 5.90

80.55 ± 7.64

82.10 ± 8.14

UREA (mmol/L)

7.90 ± 1.65

8.81 ± 1.08

9.97 ± 2.19*

10.23 ± 0.65

CREA (mmol/L)

54.20 ± 8.09

52.80 ± 8.69

56.80 ± 7.34

79.70 ± 13.32*△

CHOL (mmol/L)

1.64 ± 0.15

1.53 ± 0.33

1.62 ± 0.40

1.67 ± 0.33

TG (mmol/L)

0.98 ± 0.11

1.07 ± 0.17

0.90 ± 0.13

1.10 ± 0.25

GLU (mmol/L)

1.87 ± 0.13

1.89 ± 0.29

1.70 ± 0.35

1.78 ± 0.30

105

ALT (U/L)

132.90 ± 20.10

158.60 ± 17.18*

159.90 ± 19.11*

162.30 ± 8.16*

AST (U/L)

165.40 ± 15.05

200.20 ± 21.69*

200.00 ± 16.95*

242.30 ± 32.88*△

ALP (U/L)

141.60 ± 23.16

195.80 ± 63.17

197.40 ± 83.28

240.0 ± 165.90

T-B IL (mmol/L)

0.51 ± 0.30

0.39 ± 0.33

0.52 ± 0.28

0.75 ± 0.43

D-B IL (mmol/L)

0.76 ± 0.21

1.17 ± 0.76

0.93 ± 0.38

0.85 ± 0.49

TP (mmol/L)

76.57 ± 6.51

80.51 ± 3.44

79.41 ± 4.55

80.03 ± 9.74

UREA (mmol/L)

7.32 ± 1.32

8.00 ± 1.80

8.26 ± 2.04

10.63 ± 1.14*△

CREA (mmol/L)

40.10 ± 3.25

48.80 ± 6.97*

51.30 ± 7.54*

62.60 ± 3.77*△

CHOL (mmol/L)

1.35 ± 0.19

1.52 ± 0.32

1.61 ± 0.24

1.49 ± 0.60

TG (mmol/L)

1.13 ± 0.26

0.85 ± 0.30

1.04 ± 0.33

1.03 ± 0.46

 

GLU (mmol/L)

4.26 ± 0.84

4.21 ± 0.65

3.91 ± 0.51

4.48 ± 0.73

  1. Most serum biochemical parameters were within the normal range, except the pharmacological effects ALT in 90 d treated groups, AST, UREA, and CREA in 90 and 105 days treated groups, after a 13-week POM93 oral treatment. The results are shown as average ± S.D. (n = 20), *P < 0.05 versus control and △ P < 0.05 versus 62.2 mg/kg groups by one-way ANOVA
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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