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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

Fig. 1

Comparison of systolic (a) and diastolic blood pressure (b) from WKY, WKY + SAL, GK, and GK + SAL rats. SAL was administrated with different dosage of 50, 100 and 200 mg/kg/day for 4 weeks in Experiment I, Experiment II, and Experiment III, respectively. Chronic administration of 50 mg/kg/day SAL had no obvious effects on systolic (a) and diastolic blood pressure (b) in WKY or GK rats, respectively. However, chronic administration of 100 mg/kg/day SAL significantly reduced the blood pressure in diabetic GK, whereas did not affect the blood pressure in control WKY rats. In addition, chronic administration of 200 mg/kg/day SAL significantly decreased systolic (a) and diastolic blood pressure (b) in both WKY and GK rats, respectively. These results indicated that dosage of 100 mg/kg/day SAL is effective for lowering blood pressure in diabetic GK rats. Values are expressed as means ± SEM and n = 10 animals in each group. *P < 0.05 vs. WKY rats and #P < 0.05 vs. GK rats

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