Table 2 Drugs grouped by Anatomical Therapeutic Chemical (ATC) classification code and their relative distribution in clusters C1–C4 based on the similarity of their predicted adverse drug reactions induced by synergistic drug-drug interactions (ADRs)

A

Alimentary tract and metabolism

64

10

12

14

10

8

~

B

Blood and blood forming organs

12

2

2

1

1

4

~

C

Cardiovascular system

88

14

22

24

11

8

+ +

D

Dermatologicals

19

3

2

0

4

5

–

G

Genito/urinary system and sex hormones

28

5

0

4

6

7

–

H

Systemic hormonal preparations

9

1

0

1

<1

4

–

J

Anti-infectives for systemic use

34

6

6

7

5

5

~

L

Antineoplastic and immune-modulating agents

61

10

1

1

11

20

– –

M

Musculo-skeletal system

45

7

16

7

4

5

+ +

N

Nervous system

167

27

29

28

31

21

~

P

Anti-parasitic products, insecticides, and repellents

10

2

0

0

2

3

–

R

Respiratory system

49

8

6

11

8

7

~

S

Sensory organs

11

2

2

1

2

2

~

V

Various

16

3

3

2

3

2

~