Skip to main content

Table 2 Drugs grouped by Anatomical Therapeutic Chemical (ATC) classification code and their relative distribution in clusters C1–C4 based on the similarity of their predicted adverse drug reactions induced by synergistic drug-drug interactions (ADRs)

From: Data-driven prediction of adverse drug reactions induced by drug-drug interactions

ATC code Classification All drugs C1
%
C2
%
C3
%
C4
%
ADR
N %
A Alimentary tract and metabolism 64 10 12 14 10 8 ~
B Blood and blood forming organs 12 2 2 1 1 4 ~
C Cardiovascular system 88 14 22 24 11 8 + +
D Dermatologicals 19 3 2 0 4 5
G Genito/urinary system and sex hormones 28 5 0 4 6 7
H Systemic hormonal preparations 9 1 0 1 <1 4
J Anti-infectives for systemic use 34 6 6 7 5 5 ~
L Antineoplastic and immune-modulating agents 61 10 1 1 11 20 – –
M Musculo-skeletal system 45 7 16 7 4 5 + +
N Nervous system 167 27 29 28 31 21 ~
P Anti-parasitic products, insecticides, and repellents 10 2 0 0 2 3
R Respiratory system 49 8 6 11 8 7 ~
S Sensory organs 11 2 2 1 2 2 ~
V Various 16 3 3 2 3 2 ~
  1. Only drugs that have an ATC classification are included. The last column indicates the propensity of ADRs to be preferentially associated with compounds in clusters C1 and C2 (+ +), have no preferential association with drugs in any cluster (~), or be preferentially associated with compounds in clusters C3 and C4 (– or – –), respectively. Each column sums to 100% and the values indicate the distribution of drugs among the ATC classification for each cluster. The number of DDI-induced ADRs for each drug was highly variable, indicating no systematic variation of DDI-induced ADRs on a per drug basis among the ATC drug classes