Skip to main content

Table 3 Predicted distribution of different drug classes associated with four adverse drug reactions (ADRs)

From: Data-driven prediction of adverse drug reactions induced by drug-drug interactions

ATC Classification Spontaneous abortion Vestibular disorder Heat stroke Rheumatic heart disease
N M S N M S N M S N M S
(%) (%) (%) (%)
A Alimentary tract and metabolism 10 13 13 12 2 7 10 14 9 11 9 5
B Blood and blood forming organs 2 0 2 2 0 0 3 0 0 2 0 0
C Cardiovascular system 17 1 11 9 35 39 18 10 3 11 45 24
D Dermatologicals 3 1 2 4 2 0 4 1 1 3 2 0
G Genito/urinary system and sex hormones 4 11 0 5 3 5 6 4 1 5 0 0
H Systemic hormonal preparations 2 0 0 2 2 0 2 0 0 2 2 0
J Anti-infectives for systemic use 7 4 0 6 9 0 6 8 4 6 2 0
L Antineoplastic and immune-modulating agents 12 0 2 12 5 0 15 0 0 10 9 5
M Musculo-skeletal system 8 6 4 6 14 8 8 7 6 7 6 7
N Nervous system 20 47 63 27 15 40 14 31 69 25 19 60
P Anti-parasitic products, insecticides, and repellents 2 2 0 2 0 0 2 2 0 2 0 0
R Respiratory system 7 15 4 9 8 0 6 18 6 9 0 0
S Sensory organs 2 0 0 2 3 2 2 4 0 2 0 0
V Various 3 0 0 3 3 0 4 0 1 2 6 0
  1. We classified the drugs by two-way clustering of their DDI-induced ADR scores calculated from equation (3) into three categories: no ADR induction (category N), moderate ADR induction (category M), and strong ADR induction (category S). Fractions in categories M and S that are twice as large as the fraction in category N are indicated in bold. The columns sum to 100%, and the values characterize the distribution of drugs among the Anatomical Therapeutic Chemical (ATC) classifications for each cluster