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Table 3 Predicted distribution of different drug classes associated with four adverse drug reactions (ADRs)

From: Data-driven prediction of adverse drug reactions induced by drug-drug interactions

ATC Classification

Spontaneous abortion

Vestibular disorder

Heat stroke

Rheumatic heart disease

N

M

S

N

M

S

N

M

S

N

M

S

(%)

(%)

(%)

(%)

A

Alimentary tract and metabolism

10

13

13

12

2

7

10

14

9

11

9

5

B

Blood and blood forming organs

2

0

2

2

0

0

3

0

0

2

0

0

C

Cardiovascular system

17

1

11

9

35

39

18

10

3

11

45

24

D

Dermatologicals

3

1

2

4

2

0

4

1

1

3

2

0

G

Genito/urinary system and sex hormones

4

11

0

5

3

5

6

4

1

5

0

0

H

Systemic hormonal preparations

2

0

0

2

2

0

2

0

0

2

2

0

J

Anti-infectives for systemic use

7

4

0

6

9

0

6

8

4

6

2

0

L

Antineoplastic and immune-modulating agents

12

0

2

12

5

0

15

0

0

10

9

5

M

Musculo-skeletal system

8

6

4

6

14

8

8

7

6

7

6

7

N

Nervous system

20

47

63

27

15

40

14

31

69

25

19

60

P

Anti-parasitic products, insecticides, and repellents

2

2

0

2

0

0

2

2

0

2

0

0

R

Respiratory system

7

15

4

9

8

0

6

18

6

9

0

0

S

Sensory organs

2

0

0

2

3

2

2

4

0

2

0

0

V

Various

3

0

0

3

3

0

4

0

1

2

6

0

  1. We classified the drugs by two-way clustering of their DDI-induced ADR scores calculated from equation (3) into three categories: no ADR induction (category N), moderate ADR induction (category M), and strong ADR induction (category S). Fractions in categories M and S that are twice as large as the fraction in category N are indicated in bold. The columns sum to 100%, and the values characterize the distribution of drugs among the Anatomical Therapeutic Chemical (ATC) classifications for each cluster