Fig. 5

Exendin-4 and L-165,041 inhibit AGE-induced cell death of RMC. AGE enhanced death of RMC. Both exendin-4 (a) and L-165,041 (b) significantly attenuated AGE-induced cell death. The effect of L-165,041 was reversed by siRNA of PPARδ. No synergic effect between exendin-4 and L-165,041 in inhibiting AGE-induced cell death was noted. Exendin-4 or L-165,041 alone showed no influence on cell survival in the absence of AGE. (N = 6) *P < 0.05 when compared to control. +P < 0.05 when compared to AGE group