|
Methylxanthines
|
Injected dose (ng/ embryo)
|
|---|
|
Aminophylline
|
0.5
|
1.25
|
2.5*
|
3.75
|
5
|
|
Caffeine
|
0.25
|
0.5
|
0.75*
|
1.5
|
2.5
|
|
Diprophylline
|
1
|
2.5
|
5*
|
10
|
20
|
|
Doxofylline
|
1
|
2
|
3*
|
5
|
7.5
|
|
Etophylline
|
0.5
|
1
|
2*
|
3
|
5
|
|
IBMX
|
0.15
|
0.25
|
0.5*
|
0.75
|
1
|
|
Pentoxifylline
|
0.15
|
0.5
|
1*
|
2
|
3
|
|
Theophylline
|
0.25
|
0.5
|
1*
|
1.5
|
2.5
|
|
Dichloroaniline
|
0.015
|
0.05
|
0.1*
| | |
|
Metoprolol
|
0.005
|
0.01
|
0.018*
|
0.037
|
0.075
|
- The doses labeled with asterisk (*) were selected for the experiments in the transgenic tg (Bmp:EGFP) embryos to study the long term effect of methylxanthines in heart rate. Dichloroaniline was used as positive control in evaluation of mortality and general morphology, and metoprolol was used as internal control in evaluation of heart rate
