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Table 7 Logistic regression analysis

From: Frequency, characteristics and risk factors of QT interval prolonging drugs and drug-drug interactions in cancer patients: a multicenter study

Variables

OR (95% CI)

p-value

Gender

 Female

1 (0.7–1.6)

0.7

Age categories

  ≤ 30

Reference

 31–40

0.8 (0.4–1.7)

0.6

 41–50

1.4 (0.8–2.6)

0.3

  > 50

1 (0.6–1.7)

1

Overall prescribed drugs

  ≤ 5

Reference

 6–7

3.5 (0.9–12.9)

0.07

 8–9

8.9 (2.6–30.3)

<0.001

  ≥ 10

25.2 (7.7–82.2)

<0.001

QT drugs

 1

Reference

 2

25.4 (11.2–57.5)

<0.001

  ≥ 3

21 (9.2–48)

<0.001

Diagnoses

 Acute lymphoblastic leukemia

Reference

 Breast cancer

3.7 (1.2–11.6)

0.03

 Chronic lymphocytic leukemia

3.5 (0.8–15.9)

0.1

 Gastrointestinal cancer

4 (1.3–13)

0.02

 Genitourinary cancer

2.7 (0.7–10.9)

0.2

 Gynecologic cancer

3.1 (0.9–11.2)

0.08

 Musculoskeletal cancer

2.5 (0.5–12)

0.3

 Non hodgkin lymphoma

0.3 (0.07–1.3)

0.1

 Others

1 (0.3–3.3)

0.9

Anticancer drugs

  ≤ 2

Reference

 

  > 2

0.6 (0.4–0.9)

0.02

Supportive care drugs

  ≤ 3

Reference

 

 4–5

4.3 (1.9–9.5)

<0.001

 6–8

8.1 (3.7–17.7)

<0.001

  > 8

12.2 (4.9–30.5)

<0.001