|
Presence of adverse events
|
|
Diarrhea
|
31 (65%)
|
12 (41%)
|
19 (100%)
|
<0.0001
|
|
Moderate-to-severe (≥ Grade 2)
|
3 (6%)
|
1 (3%)
|
2 (11%)
|
0.3218
|
|
Stomatitis
|
10 (21%)
|
5 (17%)
|
5 (26%)
|
0.4490
|
|
Moderate-to-severe (≥ Grade 2)
|
2 (4%)
|
0 (0%)
|
2 (11%)
|
0.0743
|
|
Paronychia
|
24 (50%)
|
14 (48%)
|
10 (53%)
|
0.7679
|
|
Moderate-to-severe (≥ Grade 2)
|
13 (27%)
|
9 (31%)
|
4 (21%)
|
0.4466
|
|
Skin rash and/or acneiform eruption
|
41 (85%)
|
25 (86%)
|
16 (84%)
|
0.8480
|
|
Moderate-to-severe (≥ Grade 2)
|
8 (17%)
|
4 (14%)
|
4 (21%)
|
0.5093
|
|
Dry skin
|
34 (71%)
|
20 (69%)
|
14 (74%)
|
0.7250
|
|
Moderate-to-severe (≥ Grade 2)
|
1 (2%)
|
0 (0%)
|
1 (5%)
|
0.2118
|
|
Pruritus
|
12 (25%)
|
6 (21%)
|
6 (32%)
|
0.3942
|
|
Moderate-to-severe (≥ Grade 2)
|
0 (0%)
|
0 (0%)
|
0 (0%)
| |
|
Details of adverse events
|
|
Diarrhea
| | | |
0.0004
|
|
Grade 0
|
17 (35%)
|
17 (59%)
|
0 (0%)
| |
|
Grade 1
|
28 (58%)
|
11 (38%)
|
17 (89%)
| |
|
Grade 2
|
2 (4%)
|
1 (3%)
|
1 (5%)
| |
|
Grade 3
|
1 (2%)
|
0 (0%)
|
1 (5%)
| |
|
Stomatitis
| | | |
0.2033
|
|
Grade 0
|
38 (79%)
|
24 (83%)
|
14 (74%)
| |
|
Grade 1
|
8 (17%)
|
5 (17%)
|
3 (16%)
| |
|
Grade 2
|
2 (4%)
|
0 (0%)
|
2 (11%)
| |
|
Paronychia
| | | |
0.1013
|
|
Grade 0
|
24 (50%)
|
15 (52%)
|
9 (47%)
| |
|
Grade 1
|
11 (23%)
|
5 (17%)
|
6 (32%)
| |
|
Grade 2
|
9 (19%)
|
8 (28%)
|
1 (5%)
| |
|
Grade 3
|
4 (8%)
|
1 (3%)
|
3 (16%)
| |
|
Skin rash and/or acneiform eruption
| | | |
0.1354
|
|
Grade 0
|
7 (15%)
|
4 (14%)
|
3 (16%)
| |
|
Grade 1
|
33 (69%)
|
21 (72%)
|
12 (63%)
| |
|
Grade 2
|
5 (10%)
|
4 (14%)
|
1 (5%)
| |
|
Grade 3
|
3 (6%)
|
0 (0%)
|
3 (16%)
| |
|
Dry skin
| | | |
0.4461
|
|
Grade 0
|
14 (29%)
|
9 (31%)
|
5 (26%)
| |
|
Grade 1
|
33 (69%)
|
20 (69%)
|
13 (68%)
| |
|
Grade 2
|
1 (2%)
|
0 (0%)
|
1 (5%)
| |
|
Pruritus
| | | |
0.3942
|
|
Grade 0
|
36 (75%)
|
23 (79%)
|
13 (68%)
| |
|
Grade 1
|
12 (25%)
|
6 (21%)
|
6 (32%)
| |
