|
ATLAS-ACS 2 TIMI 51 [11]
|
Cardiac death + stroke + MI (composite endpoint), cardiac death, MI, stroke, all-cause death, ST, TIMI minor and major bleeding, Intracranial hemorrhage, fatal bleeding
|
13 to 31 months
|
Rivaroxaban + DAPT versus DAPT (aspirin + clopidogrel)
|
2.5 mg or 5 mg twice daily
|
|
GEMINI-ACS-1 [12]
|
Cardiac death + stroke + MI + ST (composite endpoint), cardiac death, MI, stroke, all-cause death, ST (definite + probable), TIMI minor and major bleeding, fatal bleeding, intracranial hemorrhage, ISTH major bleeding
|
1 year
|
Ribaroxaban + clopidogrel/ticagrelor versus aspirin + clopidogrel/ticagrelor
|
2.5 mg twice daily
|
|
COMPASS [13]
|
Cardiac death + stroke + MI (composite endpoint), all-cause death, cardiac death, stroke, MI, fatal bleeding, intracranial hemorrhage, major bleeding according to ISTH criteria
|
23 months
|
Rivaroxaban + aspirin versus aspirin alone
|
2.5 mg or 5 mg twice daily
|
|
ATLAS-ACS-TIMI 46 [14]
|
TIMI minor and major bleeding, death + MI + stroke (composite endpoint)
|
6 months
|
Rivaroxaban + DAPT or aspirin versus DAPT (aspirin + clopidogrel)
|
5 to 20 mg once daily or the same total dose given twice daily
|
