Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series

Table 2 Biochemical parameters in the C and F group

Biochemical parameters^*		C group		F group	Df	P value	Ref. range
Biochemical parameters^*	n	mean±SD or median (IQ range)	n	mean±SD or median (IQ range)	Df	P value	Ref. range
Blood
PH^#	37	7.36(7.33–7.39)	4	7.32(7.28–7.36)	–	0.109^b	7.35–7.45
Phos. (mmol/L)	117	0.54 ± 0.15	31	0.49 ± 0.14	146	0.115^a	0.81–1.45
Ca²⁺ (mmol/L)	81	2.18 ± 0.13	19	2.11 ± 0.28	98	0.305^a	2.25–2.75
K⁺ (mmol/L)	80	3.48 ± 0.40	10	3.75 ± 0.42	88	0.048^a	3.5–5.5
UA (umol/L)	65	110(90.65–131.85)	13	107(95.20–152.85)	–	0.406^b	210–420
BG (mmol/L)	33	5.02(4.75–5.36)	4	5.55(4.70–5.93)	–	0.352^b	3.9–5.6
SCr (umol/L)	69	107.71 ± 28.75	19	115.65 ± 32.20	86	0.302^a	44.2–88.4
25-(OH)VitD3 (ng/ml) ^&	42	15.45(12.90–21.75)	9	23.50(11.80–29.80)	–	0.236^b	9–52
PTH (ng/ml)	52	30.56(23.84–48.22)	18	28.37(20.00–46.96)	–	0.657^b	15–65
AKP (IU/L)	94	240.5(179.8–317.0)	25	698(324.5–1160.0)	–	<0.001^b	40–150
Urine
Phos./24 h (mmol/24 h)	35	18.81 ± 10.39	8	21.69 ± 8.98	41	0.473^a	12.9–42.0
Ca²⁺ /24 h (mmol/24 h)	26	9.23 ± 4.31	9	7.19 ± 4.50	33	0.234^a	2.5–7.5
Protein/24 h (mmol/24 h)	34	1.00 ± 0.49	10	1.16 ± 0.43	42	0.361^a	< 0.15
NAG (U/L)	10	35.5 (27.0–55.15)	4	22.8 (13.65–43.35)	–	0.239^b	2–18
β2-MG (mg/L)	14	13.71 (5.13–81.3)	4	77.1 (50.58–119.32)	–	0.110^b	< 0.2

*Different sample size has been given for different parameters in the C and the F group order
^#Only 3 patients had urine PH record, they were 6.5, 7.5, 7.5, respectively
^aTwo independent sample t test
^bTwo independent sample Mann-Whitney U test
^&The range was set according to published reports [13,14,15,16,17]

ISSN: 2050-6511