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Table 2 Biochemical parameters in the C and F group

From: Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series

Biochemical parameters*   C group   F group Df P value Ref. range
n mean±SD or
median (IQ range)
n mean±SD or
median (IQ range)
Blood
 PH# 37 7.36(7.33–7.39) 4 7.32(7.28–7.36) 0.109b 7.35–7.45
 Phos. (mmol/L) 117 0.54 ± 0.15 31 0.49 ± 0.14 146 0.115a 0.81–1.45
 Ca2+ (mmol/L) 81 2.18 ± 0.13 19 2.11 ± 0.28 98 0.305a 2.25–2.75
 K+ (mmol/L) 80 3.48 ± 0.40 10 3.75 ± 0.42 88 0.048a 3.5–5.5
 UA (umol/L) 65 110(90.65–131.85) 13 107(95.20–152.85) 0.406b 210–420
 BG (mmol/L) 33 5.02(4.75–5.36) 4 5.55(4.70–5.93) 0.352b 3.9–5.6
 SCr (umol/L) 69 107.71 ± 28.75 19 115.65 ± 32.20 86 0.302a 44.2–88.4
 25-(OH)VitD3 (ng/ml) & 42 15.45(12.90–21.75) 9 23.50(11.80–29.80) 0.236b 9–52
 PTH (ng/ml) 52 30.56(23.84–48.22) 18 28.37(20.00–46.96) 0.657b 15–65
 AKP (IU/L) 94 240.5(179.8–317.0) 25 698(324.5–1160.0) <0.001b 40–150
Urine
 Phos./24 h (mmol/24 h) 35 18.81 ± 10.39 8 21.69 ± 8.98 41 0.473a 12.9–42.0
 Ca2+ /24 h (mmol/24 h) 26 9.23 ± 4.31 9 7.19 ± 4.50 33 0.234a 2.5–7.5
 Protein/24 h (mmol/24 h) 34 1.00 ± 0.49 10 1.16 ± 0.43 42 0.361a < 0.15
 NAG (U/L) 10 35.5 (27.0–55.15) 4 22.8 (13.65–43.35) 0.239b 2–18
 β2-MG (mg/L) 14 13.71 (5.13–81.3) 4 77.1 (50.58–119.32) 0.110b < 0.2
  1. *Different sample size has been given for different parameters in the C and the F group order
  2. #Only 3 patients had urine PH record, they were 6.5, 7.5, 7.5, respectively
  3. aTwo independent sample t test
  4. bTwo independent sample Mann-Whitney U test
  5. &The range was set according to published reports [13,14,15,16,17]