Table 3 Percent recovery of unchanged puerarin and puerarin glucuronide after administration of puerarin at 1 mg/kg IV and 5 and 10 mg/kg PO
From: Absolute oral bioavailability and disposition kinetics of puerarin in female rats
Recovery (%) | Administration of Puerarin | ||
|---|---|---|---|
1 mg/kg IV | 5 mg/kg PO | 10 mg/kg PO | |
Puerarin | |||
Urine0-24h | < 1.00 | < 1.00 | < 1.00 |
Urine24-48h | < 1.00 | < 1.00 | < 1.00 |
Urine48-72h | < 1.00 | < 1.00 | < 1.00 |
Faeces0-24h | < 1.00 | < 1.00 | < 1.00 |
Faeces24-48h | < 1.00 | < 1.00 | < 1.00 |
Faeces48-72h | < 1.00 | < 1.00 | < 1.00 |
Puerarin glucuronide | |||
Urine0-24h | 47.53 ± 51.37 | < 1.00 | 12.13 ± 13.01 |
Urine24-48h | 2.38 ± 0.97* | < 1.00 | < 1.00 |
Urine48-72h | 1.89 ± 0.45* | < 1.00 | < 1.00 |
Faeces0-24h | 7.66 ± 2.51* | < 1.00 | 1.94 ± 2.16 |
Faeces24-48h | 3.55 ± 0.55* | < 1.00 | < 1.00 |
Faeces48-72h | 3.45 ± 0.80* | < 1.00 | < 1.00 |