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Table 3 Percent recovery of unchanged puerarin and puerarin glucuronide after administration of puerarin at 1 mg/kg IV and 5 and 10 mg/kg PO

From: Absolute oral bioavailability and disposition kinetics of puerarin in female rats

Recovery (%) Administration of Puerarin
1 mg/kg IV 5 mg/kg PO 10 mg/kg PO
Puerarin
 Urine0-24h < 1.00 < 1.00 < 1.00
 Urine24-48h < 1.00 < 1.00 < 1.00
 Urine48-72h < 1.00 < 1.00 < 1.00
 Faeces0-24h < 1.00 < 1.00 < 1.00
 Faeces24-48h < 1.00 < 1.00 < 1.00
 Faeces48-72h < 1.00 < 1.00 < 1.00
Puerarin glucuronide
 Urine0-24h 47.53 ± 51.37 < 1.00 12.13 ± 13.01
 Urine24-48h 2.38 ± 0.97* < 1.00 < 1.00
 Urine48-72h 1.89 ± 0.45* < 1.00 < 1.00
 Faeces0-24h 7.66 ± 2.51* < 1.00 1.94 ± 2.16
 Faeces24-48h 3.55 ± 0.55* < 1.00 < 1.00
 Faeces48-72h 3.45 ± 0.80* < 1.00 < 1.00
  1. Data are presented as mean ± S.D. (n = 4). *p < 0.05 among doses