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Table 2 General features of the studies

From: Adverse clinical outcomes associated with double dose clopidogrel compared to the other antiplatelet regimens in patients with coronary artery disease: a systematic review and meta-analysis

Studies

No of patients in the DDC group (n)

No of patients in control group (n)

Year of patients’ enrollment

Type of study

Type of participants

CURRENT OASIS 7

8560

8703

2006–2009

RCT

ACS + PCI

OPTIMUS2007

20

20

–

Pilot study

DM + CAD

Khatri2013

26

64

2009–2010

Retrospective study

CAD

OPTIMUS3

35

34

2008–2009

RCT

DM + CAD

PRINCIPLE TIMI 44

99

102

–

RCT

Any CAD with planned PCI

Tailor2014

52

54

2010–2012

RCT

CAD + ACS

Chen2017

50

57 + 46

2012–2014

OC

CAD

Wu2017

20

20

2014–2015

RCT

CAD with planned PCI

ACCEL AMI

30

30 + 30

–

RCT

AMI

ACCEL DM

39

41

–

RCT

DM + AMI undergoing PCI

CREATIVE

359

362 + 355

2012–2015

RCT

CAD + PCI

Ha2013

21

21

–

RCT

DM + PCI

HOST ASSURE

1876

1879

2010–2011

RCT

CAD + PCI

Jeong2009

30

30

–

RCT

CAD + PCI

Total number of patients (n)

11,217

11,848

   
  1. Abbreviations: ACS: acute coronary syndrome, PCI: percutaneous coronary intervention, DM: diabetes mellitus, CAD: coronary artery disease, AMI: acute myocardial infarction, RCT: randomized controlled trials, OC: observational studies; DDC: double dose clopidogrel