|
Studies
|
No of patients in the DDC group (n)
|
No of patients in control group (n)
|
Year of patients’ enrollment
|
Type of study
|
Type of participants
|
|---|
|
CURRENT OASIS 7
|
8560
|
8703
|
2006–2009
|
RCT
|
ACS + PCI
|
|
OPTIMUS2007
|
20
|
20
|
–
|
Pilot study
|
DM + CAD
|
|
Khatri2013
|
26
|
64
|
2009–2010
|
Retrospective study
|
CAD
|
|
OPTIMUS3
|
35
|
34
|
2008–2009
|
RCT
|
DM + CAD
|
|
PRINCIPLE TIMI 44
|
99
|
102
|
–
|
RCT
|
Any CAD with planned PCI
|
|
Tailor2014
|
52
|
54
|
2010–2012
|
RCT
|
CAD + ACS
|
|
Chen2017
|
50
|
57 + 46
|
2012–2014
|
OC
|
CAD
|
|
Wu2017
|
20
|
20
|
2014–2015
|
RCT
|
CAD with planned PCI
|
|
ACCEL AMI
|
30
|
30 + 30
|
–
|
RCT
|
AMI
|
|
ACCEL DM
|
39
|
41
|
–
|
RCT
|
DM + AMI undergoing PCI
|
|
CREATIVE
|
359
|
362 + 355
|
2012–2015
|
RCT
|
CAD + PCI
|
|
Ha2013
|
21
|
21
|
–
|
RCT
|
DM + PCI
|
|
HOST ASSURE
|
1876
|
1879
|
2010–2011
|
RCT
|
CAD + PCI
|
|
Jeong2009
|
30
|
30
|
–
|
RCT
|
CAD + PCI
|
|
Total number of patients (n)
|
11,217
|
11,848
| | | |
- Abbreviations: ACS: acute coronary syndrome, PCI: percutaneous coronary intervention, DM: diabetes mellitus, CAD: coronary artery disease, AMI: acute myocardial infarction, RCT: randomized controlled trials, OC: observational studies; DDC: double dose clopidogrel
