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Table 2 General features of the studies

From: Adverse clinical outcomes associated with double dose clopidogrel compared to the other antiplatelet regimens in patients with coronary artery disease: a systematic review and meta-analysis

Studies No of patients in the DDC group (n) No of patients in control group (n) Year of patients’ enrollment Type of study Type of participants
CURRENT OASIS 7 8560 8703 2006–2009 RCT ACS + PCI
OPTIMUS2007 20 20 Pilot study DM + CAD
Khatri2013 26 64 2009–2010 Retrospective study CAD
OPTIMUS3 35 34 2008–2009 RCT DM + CAD
PRINCIPLE TIMI 44 99 102 RCT Any CAD with planned PCI
Tailor2014 52 54 2010–2012 RCT CAD + ACS
Chen2017 50 57 + 46 2012–2014 OC CAD
Wu2017 20 20 2014–2015 RCT CAD with planned PCI
ACCEL AMI 30 30 + 30 RCT AMI
ACCEL DM 39 41 RCT DM + AMI undergoing PCI
CREATIVE 359 362 + 355 2012–2015 RCT CAD + PCI
Ha2013 21 21 RCT DM + PCI
HOST ASSURE 1876 1879 2010–2011 RCT CAD + PCI
Jeong2009 30 30 RCT CAD + PCI
Total number of patients (n) 11,217 11,848    
  1. Abbreviations: ACS: acute coronary syndrome, PCI: percutaneous coronary intervention, DM: diabetes mellitus, CAD: coronary artery disease, AMI: acute myocardial infarction, RCT: randomized controlled trials, OC: observational studies; DDC: double dose clopidogrel