A rare case report of heavy dose colchicine induced acute kidney injury

Table 1 Laboratory test and time of CRRT treatment

Date	Time of CRRT treatment(hour)	total Ultrafiltration volume(mL)	urine volume (mL)	Lac (0.5–1.8)mmol/L	Cr (44.0–133.0)μmol/L	BUN (2.90–8.20)mmol/L	electrolyte imbalance	WBC (3.5–9.5) × 10^9/L	RBC (3.80–5.10) × 10^12/L	HGB (115–150)g/L	PLT (100–300)10^9/L
2018.01.26③	31.5	8820	< 100	2.9	160.2	16.46	no	3.7	1.63	49	11
2018.01.27	25	3920	< 100	1.4	179.9	21.59	no	2.5	2.3	67	10
2018.01.29④	28	6000	< 100	2.5	*①	*	no	9.6	2.43	73	11
2018.01.31	22	7770	< 100	2	*	*	no	22.4	2.75	81	8
2018.02.01	16	5680	< 100	2.1	224	48.67⑤	no	34.4	2.3	68	7
2018.02.03	29.5	8160	< 100	1.3	*	*	no	35.3	1.97	59	8
2018.02.04	16.5	5270	< 100	*	*	*	no	*	*	*	*
2018.02.05	8.5	4050	< 100	1.3	206.8	40.41	no	42	2.2	68	59
2018.02.06⑥	10	3630	< 100	0.9	272.4	42.97	hypocalcemia		*	*	*
2018.02.08	8.5	1890	< 100	1.6	*	*	hypocalcemia	31.2	1.95	62	88
2018.02.09	4	690	< 100	1.1	*	*	hypocalcemia	37.9	1.32	44	76
2018.02.10	23	8700	< 100	1.2	*	*	hypocalcemia	46.4	2.16	97	101
2018.02.14	16.5	6900	< 100	0.9	259.3	18.4	hypocalcemia	11.4	1.75	59	152
2018.02.15	16	4580	< 100	0.8	276.7	23.3	no	*	*	*	*
2018.02.18⑦	12.5	6100	< 100	0.6	250.3	14.33	no	8.2	1.61	55	83
2018.02.21⑧	14	6800	< 100	0.8	*	*	no	5.8	1.63	56	88
2018.02.23	7.5	3360	< 100	*	*	*	no	*	*	*	*
2018.02.26	14	4470	< 400	1.1	303.6	19.6	no	6.5	1.17	48	352
2018.03.02	*	*	1000	*	332.5	26.83	no	7.2	2	71	445
2018.03.04	*	*	3100	*	351.1⑨	25.2	no	7.5	2.18	75	381.5
2018.03.09	*	*	1800②	*	165.7	8.72	no	7.7	2.36	79	324
2018.03.15	*	*	normal	*	102	6.14	no	10.35	2.88	88	308
2018.03.27	*	*	normal	*	51.1	6.1	no	9.4	3.36	98	281
2018.05.28	*	*	normal	*	61.6	6.8	no	7.5	4.12	118	213

Note:① *: That item was not administered that day. ②Diuretics were discontinued.③Pancytopenia and coagulation abnormalities were present.④Liver function test showed: AST 3283u/l, ALT 813 u/l; AFU103u/l. Besides, the patient developed shortness of breath and comatose. Mechanical ventilation was then performed. ⑤The BUN level and PLT count were life-threatening. ⑥FIB 0.56 g/L, D-Dimer 25.26μg/ml with no active bleeding; one possible cause was colchicine intoxication. APTT> 200 s, PT17.5 s, FDP55.2μg/ml; the abnormal values might be associated with a stress reaction. ⑦Mechanical assistance was removed. ⑧Coagulation abnormalities were resolved. ⑨Intermittent hemodialysis was initiated

ISSN: 2050-6511