Table 3 Comparison of the apparent permeabilities for the apical to basal and basolateral to apical transport of five SQV SDNs to that of standard SQV and across differentiated Caco-2 monolayers after 1 hour of incubation (n = 5)

Sample

1

2

3

4

5

Mean

STDEV

p value

SQV

3.6

2.7

2.4

15

8.0

6.4

5.4

SQV SDN 05

3.2

3.1

5.1

6.2

10

5.5

2.9

p = 0.77

SQV SDN 06

1.9

4.1

8.7

3.1

13

6.2

4.7

p = 0.96

SQV SDN 07

2.0

2.0

5.1

14

10

6.7

5.3

p = 0.94

SQV SDN 09

1.8

1.4

3.4

3.4

7.2

3.4

2.3

p = 0.30

SQV SDN 13

0.7

2.1

0.6

0.3

6.2

2.0

2.5

p = 0.06

Sample

1

2

3

4

5

Mean

STDEV

p value

SQV

7.3

13

14

9.0

9.3

10

2.8

SQV SDN 05

1.8

14

14

7.6

7.9

8.9

4.9

p = 0.56

SQV SDN 06

5.2

9.7

17

7.2

8.5

9.5

4.5

p = 0.71

SQV SDN 07

6.2

14

18

8.9

12

12

4.5

p = 0.56

SQV SDN 09

3.0

5.9

12

7.2

9.2

7.4

3.3

p = 0.15

SQV SDN 13

5.9

16

14

7.9

9.5

11

4.1

p = 0.97