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Table 3 Comparison of the apparent permeabilities for the apical to basal and basolateral to apical transport of five SQV SDNs to that of standard SQV and across differentiated Caco-2 monolayers after 1 hour of incubation (n = 5)

From: Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles

a) Apical to basolateral
  PappA-B (x 10-9 cms-1)  
Sample 1 2 3 4 5 Mean STDEV p value
SQV 3.6 2.7 2.4 15 8.0 6.4 5.4  
SQV SDN 05 3.2 3.1 5.1 6.2 10 5.5 2.9 p = 0.77
SQV SDN 06 1.9 4.1 8.7 3.1 13 6.2 4.7 p = 0.96
SQV SDN 07 2.0 2.0 5.1 14 10 6.7 5.3 p = 0.94
SQV SDN 09 1.8 1.4 3.4 3.4 7.2 3.4 2.3 p = 0.30
SQV SDN 13 0.7 2.1 0.6 0.3 6.2 2.0 2.5 p = 0.06
b) Basolateral to apical
  PappB-A (x 10-9 cms-1)
Sample 1 2 3 4 5 Mean STDEV p value
SQV 7.3 13 14 9.0 9.3 10 2.8  
SQV SDN 05 1.8 14 14 7.6 7.9 8.9 4.9 p = 0.56
SQV SDN 06 5.2 9.7 17 7.2 8.5 9.5 4.5 p = 0.71
SQV SDN 07 6.2 14 18 8.9 12 12 4.5 p = 0.56
SQV SDN 09 3.0 5.9 12 7.2 9.2 7.4 3.3 p = 0.15
SQV SDN 13 5.9 16 14 7.9 9.5 11 4.1 p = 0.97