Table 4 Results of univariate and multivariate analyses of risk factors of delayed nausea among 312 cases with palonosetron receiving MEC

Age < 75 vs. ≥75 years

312

0.444

0.168

,

1.176

0.102

–

Sex Female (vs. Male)

312

1.273

0.724

,

2.239

0.402

–

Anti-cancer drug

312

 L-OHP

178

1.000

ref

1.000

ref

 CPT11

60

0.396

0.159

,

0.989

0.047

0.505

0.137

,

1.860

0.304

 CBDCA

74

0.983

0.509

,

1.898

0.960

1.769

0.533

,

5.870

0.351

Oral 5-FU

312

 Nothing

157

1.000

ref

1.000

ref

 S-1

30

0.812

0.261

,

2.530

0.720

0.671

0.144

,

3.124

0.611

 Capecitabine

125

1.817

1.011

,

3.266

0.046

2.111

0.690

,

6.458

0.190

Additional oral steroid days 2 or 3 (vs. Nothing)

312

0.654

0.370

,

1.156

0.144

–

NK1RA (vs. Nothing)

312

1.340

0.715

,

2.513

0.362

–

Primary organ

312

–

 colorectal cancer

211

1.000

ref

 gastric cancer

25

n.c.

 lung cancer

23

1.054

0.371

,

2.998

0.921

 gynecological cancer

53

1.111

0.539

,

2.291

0.776

Hb < 10 mg/dl

312

0.719

0.410

,

1.260

0.249

–

Neut < 1500/μl

312

0.632

0.181

,

2.207

0.472

–

PLT < 7.5 × 10⁴/μl

312

1.535

0.875

,

2.691

0.135

–

CRE ≥1.1 mg/dl

312

3.112

0.953

,

10.167

0.060

–

AST > 2.5 ULN

312

1.780

0.964

,

3.287

0.066

–

ALT > 2.5 ULN

312

2.166

1.122

,

4.180

0.021

2.397

1.153

,

4.984

0.019

Fever elevation > 38 °C

312

0.574

0.127

,

2.595

0.471

–

Constipation

312

0.884

0.470

,

1.664

0.702

–

Diarrhea

312

1.394

0.729

,

2.666

0.315

–

Oral mucositis

312

1.230

0.655

,

2.310

0.520

–

Taste alteration

312

1.225

0.685

,

2.190

0.493

–

Neuropathy

312

1.804

0.986

,

3.302

0.056

–

Eruption

312

1.534

0.875

,

2.690

0.135

–

General fatigue

312

3.221

1.729

,

6.000

0.000

2.652

1.380

,

5.097

0.003

NRS ≥1

312

1.125

0.613

,

2.064

0.704

–

PS

312

 0

155

1.000

ref

1.000

ref

 1

146

1.532

0.853

,

2.752

0.153

1.360

0.723

,

2.558

0.340

 2

11

4.549

1.285

,

16.101

0.019

5.748

1.392

,

23.740

0.016