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Table 2 Summary of reported adverse events by dose

From: First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

  2-Hydroxybenzylamine acetate dose Total (n = 18)
50 mg (n = 3) 100 mg (n = 3) 200 mg (n = 3) 330 mg (n = 3) 550 mg (n = 3) 825 mg (n = 3)
Any event, n (%) 3 (100) 0 1 (33) 1 (33) 0 0 5 (28)
Frequent urination 2 (67) 0 0 0 0 0 2 (11)
Headache 0 0 1 (33) 0 0 0 1 (5.5)
Itchy throat 1 (33) 0 0 0 0 0 1 (5.5)
Rash 1 (33) 0 0 0 0 0 1 (5.5)
Sleepiness 1 (33) 0 0 0 0 0 1 (5.5)
Abdominal bloating 0 0 0 1 (33) 0 0 1 (5.5)