|
Parameter
|
2-Hydroxybenzylamine acetate dose
|
|---|
|
50 mg (n = 3)
|
100 mg (n = 3)
|
200 mg (n = 3)
|
330 mg (n = 3)
|
550 mg (n = 3)
|
825 mg (n = 3)
|
|---|
|
Half-life (h)
|
2.04
|
2.33
|
2.03
|
1.77
|
2.32
|
2.13
|
|
Cmax (ng/mL)
|
90
|
156
|
369
|
669
|
1636
|
2510
|
|
tmax (h)
|
1.33
|
1.33
|
1.83
|
1.67
|
1.67
|
1.67
|
|
AUC (h·ng/mL)
|
396
|
622
|
1490
|
2690
|
4417
|
9053
|
|
AUCextrap (%)
|
9.1
|
11.2
|
10.0
|
8.2
|
11.2
|
10.3
|
- Cmax maximum observed plasma concentration, tmax time to reach, Cmax AUC, area under the concentration-time curve from zero to infinity, AUCextrap percentage of the AUC extrapolated from the last observed time point
- Clearance and volume of distribution are not reported due to the unknown value of F (bioavailability)
