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Table 3 Mean 2-hydroxybenzylamine pharmacokinetic parameters after a single oral dose

From: First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

Parameter

2-Hydroxybenzylamine acetate dose

50 mg (n = 3)

100 mg (n = 3)

200 mg (n = 3)

330 mg (n = 3)

550 mg (n = 3)

825 mg (n = 3)

Half-life (h)

2.04

2.33

2.03

1.77

2.32

2.13

Cmax (ng/mL)

90

156

369

669

1636

2510

tmax (h)

1.33

1.33

1.83

1.67

1.67

1.67

AUC (h·ng/mL)

396

622

1490

2690

4417

9053

AUCextrap (%)

9.1

11.2

10.0

8.2

11.2

10.3

  1. Cmax maximum observed plasma concentration, tmax time to reach, Cmax AUC, area under the concentration-time curve from zero to infinity, AUCextrap percentage of the AUC extrapolated from the last observed time point
  2. Clearance and volume of distribution are not reported due to the unknown value of F (bioavailability)
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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