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Table 7 The effect of different doses of chlorpyrifos on Balb c mice which were administered orally using interagasteral tube

From: Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis

Dose in mg/kg 10 50 90
Number of mice treated 1 1 1
Adverse effect within 24 hrs ❖ Trembling
❖ Breathing difficulty
❖ Tearing, Salivating
❖ Weak
❖ Trembling
❖ Tearing, Salivating
❖ Breathing difficulty
❖ Very weak
❖ Forceful trembling
❖ Tearing, salivating
❖ Breathing difficulty
❖ Died after 12:36 hrs
Adverse effect within 48 hrs ❖ Weak
❖ Slightly recovered
❖ Breathing difficulty
❖ Very weak
❖ Trembling
 
Adverse effect within 72 hrs ❖ Recovered ❖ Slightly recovered  
Adverse effect within 96 hrs ❖ Completely recovered ❖ Recovered  
Adverse effect within 120 hrs ❖ Weight loss ❖ Weight loss  
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