Nitratesa - PDE-5 inhibitorsb
|
Hypotension
|
0.06 (95)
|
0.05 (82)
|
0.06 (97)
|
0.08 (135)
|
LP
|
LP
|
0.04, 1.03
|
0.04, 0.81
|
0.05, 0.71
|
0.07, 0.90
|
MAO inhibitorsc - SSRIsd
|
Serotonin toxicity
|
4.09 (7118)
|
4.21 (7365)
|
4.19 (7382)
|
3.96 (6980)
|
0.07
|
DNF
|
44.92, 3.74
|
46.96, 3.92
|
49.51, 3.93
|
46.03, 3.72
|
MAO inhibitorsc - Tricyclic antidepressantse
|
Serotonin toxicity
|
0.32 (551)
|
0.26 (446)
|
0.36 (631)
|
0.53 (933)
|
0.67
|
DNF
|
3.48, 3.51
|
2.84, 2.94
|
4.23, 4.13
|
6.15, 5.52
|
MAO inhibitorsc - Narcotic analgesicsf
|
Serotonin toxicity
|
2.02 (3516)
|
2.16 (3770)
|
2.41 (4245)
|
2.41 (4252)
|
0.90
|
+ 21
|
22.19, 2.50
|
24.04, 2.52
|
28.47, 2.89
|
28.04, 2.90
|
MAO inhibitorsc - Triptansg
|
Serotonin toxicity
|
0.01 (22)
|
0.01 (13)
|
0.01 (13)
|
0.01 (16)
|
LP
|
LP
|
0.14, 0.38
|
0.08, 0.21
|
0.08, 0.18
|
0.10, 0.21
|
MAO inhibitorsc - Amphetamine derivativesh
|
Serotonin toxicity
|
0.00 (0)
|
0.00 (0)
|
0.00 (0)
|
0.00 (0)
|
LP
|
LP
|
0.00, 0.00
|
0.00, 0.00
|
0.00, 0.00
|
0.00, 0.00
|
QT prolonging agentsi - QT prolonging agentsi
|
Potentially lethal ventricular arrhythmia
|
6.50 (11301)
|
6.52 (11401)
|
6.23 (10963)
|
5.63 (9925)
|
0.76
|
−12
|
NA
|
NA
|
NA
|
NA
|
Vitamin K antagonistsj - NSAIDsk
|
Bleeding
|
44.53 (77442)
|
49.46 (86478)
|
57.10 (100563)
|
54.42 (95977)
|
0.77
|
+ 24
|
41.38, 11.23
|
46.66, 12.28
|
55.36, 13.75
|
53.94, 12.95
|
Vitamin K antagonistsj - Fibric acid derivativesl
|
Bleeding
|
16.02 (27854)
|
15.67 (27395)
|
15.13 (26639)
|
14.56 (25677)
|
0.98
|
−8
|
14.88, 38.12
|
14.78, 38.88
|
14.66, 38.54
|
14.43, 37.29
|
Vitamin K antagonistsj - Barbituratesm
|
Reduced anticoagulant effect
|
0.47 (823)
|
0.62 (1079)
|
0.58 (1020)
|
0.78 (1376)
|
0.81
|
+ 67
|
0.44, 15.54
|
0.58, 21.81
|
0.56, 16.73
|
0.77, 17.72
|
Simvastatin - CYP3A4 inhibitorsn
|
Statin toxicity (e.g. rhabdomyolysis)
|
13.81 (24013)
|
11.14 (19471)
|
8.96 (15774)
|
7.33 (12921)
|
0.99
|
−46
|
18.89, 20.39
|
18.87, 16.49
|
18.95, 13.57
|
18.07, 12.52
|
Theophylline - Ciprofloxacin
|
Theophylline toxicity (e.g. seizures, hypotension)
|
2.81(4884)
|
2.65 (4626)
|
2.62 (4620)
|
2.19 (3870)
|
0.81
|
−21
|
5.33, 8.86
|
5.14, 8.24
|
5.25, 8.47
|
4.64, 7.80
|
Theophylline - Fluvoxamine
|
Theophylline toxicity (e.g. seizures, hypotension)
|
0.15 (261)
|
0.12 (200)
|
0.06 (111)
|
0.24 (414)
|
0.14
|
DNF
|
0.25, 7.97
|
0.20, 6.88
|
0.11, 4.49
|
0.45, 19.10
|
Tizanidine - CYP1A2 inhibitorso
|
Tizanidine toxicity (e.g. hypotension, drowsiness)
|
0.73 (1262)
|
0.70 (1228)
|
0.67 (1172)
|
0.72 (1262)
|
0.03
|
DNF
|
8.55, 1.23
|
8.57, 1.21
|
8.53, 1.19
|
7.87, 1.36
|
Alprazolam - Azole antifungalsp
|
Benzodiazepine toxicity
|
2.15 (3739)
|
2.48 (4335)
|
2.42 (4260)
|
2.33 (4110)
|
0.26
|
DNF
|
0.71, 13.35
|
0.79, 14.61
|
0.80, 13.97
|
0.78, 13.98
|
Ergot alkaloidsq - CYP3A4 inhibitorsr
|
Ergot toxicity
|
0.14 (244)
|
0.15 (260)
|
0.13 (224)
|
0.11 (196)
|
0.70
|
−19
|
2.95, 0.34
|
3.27, 0.35
|
2.96, 0.30
|
2.67, 0.30
|
Thiopuriness - Xanthine oxidase inhibitorst
|
Thiopurine toxicity (e.g. bone marrow suppression)
|
0.17 (297)
|
0.21 (365)
|
0.27 (472)
|
0.31 (546)
|
0.99
|
+ 84
|
5.46, 0.13
|
6.36, 0.15
|
7.97, 0.18
|
8.75, 0.20
|
Methotrexate - Trimethoprim
|
Methotrexate toxicity (e.g. bone marrow suppression)
|
0.00 (6)
|
0.00 (7)
|
0.01 (11)
|
0.01 (9)
|
LP
|
LP
|
0.19, 0.02
|
0.23, 0.03
|
0.32, 0.04
|
0.27, 0.03
|
Digoxin - Clarithromycin
|
Digoxin toxicity
|
0.07 (115)
|
0.05 (83)
|
0.03 (56)
|
0.04 (65)
|
LP
|
LP
|
0.60, 0.27
|
0.49, 0.19
|
0.36, 0.12
|
0.47, 0.19
|
|
Total
|
99.28 (172673)
|
101.84 (178055)
|
105.79 (186309)
|
100.18 (176686)
|
0.21
|
DNF
| | | | |