Potassium chloride - ACE inhibitorsa
|
Hyperkalemia
|
352.04 (612284)
|
355.89 (622256)
|
334.14 (588480)
|
338.53 (597064)
|
0.46
|
DNF
|
373.23, 38.45
|
390.52, 39.05
|
385.01, 36.60
|
396.43, 36.35
|
Potassium sparing diureticsb - ACE inhibitorsc
|
Hyperkalemia
|
241.56 (420132)
|
247.91 (433452)
|
240.62 (423769)
|
246.54 (434824)
|
0.38
|
DNF
|
319.27, 27.79
|
336.72, 28.45
|
335.44, 27.41
|
348.54, 27.38
|
Potassium chloride - Potassium sparing diureticsb
|
Hyperkalemia
|
85.93 (149452)
|
86.99 (152093)
|
81.10 (142823)
|
82.82 (146061)
|
0.39
|
DNF
|
91.10, 113.57
|
95.45, 118.15
|
93.44, 113.05
|
96.98, 117.08
|
Sulfamethoxazole/ trimethoprim - ACE inhibitorsc
|
Hyperkalemia
|
11.40 (19822)
|
10.64 (18603)
|
10.28 (18099)
|
9.86 (17394)
|
0.97
|
−12
|
64.28, 1.24
|
70.11, 1.17
|
65.97, 1.13
|
67.05, 1.06
|
Vitamin K antagonistsd - Platelet aggregation inhibitorse
|
Bleeding
|
93.62 (162828)
|
97.67 (170779)
|
102.49 (180508)
|
98.27 (173316)
|
0.53
|
DNF
|
87.00, 22.48
|
92.15, 23.83
|
99.36, 25.02
|
97.40, 24.71
|
NOACsf - Platelet aggregation inhibitorse
|
Bleeding
|
0.77 (1334)
|
2.84 (4961)
|
7.18 (12651)
|
12.90 (22748)
|
0.96
|
+ 1605
|
23.25, 0.18
|
36.63, 0.69
|
51.11, 1.75
|
57.70, 3.24
|
NOACsf - NSAIDsg
|
Bleeding
|
0.48 (830)
|
2.06 (3607)
|
5.08 (8944)
|
8.77 (15472)
|
0.97
|
+ 1764
|
14.47, 0.12
|
26.64, 0.51
|
36.13, 1.22
|
39.24, 2.09
|
Vitamin K antagonistsd - Amiodarone
|
Bleeding
|
17.65 (30690)
|
17.96 (31398)
|
18.02 (31741)
|
17.47 (30813)
|
0.03
|
DNF
|
16.40, 276.48
|
16.94, 279.31
|
17.47, 281.21
|
17.32, 267.92
|
Vitamin K antagonistsd - Azole antifungalsh
|
Bleeding
|
0.56 (971)
|
0.67 (1175)
|
0.57 (998)
|
0.66 (1164)
|
0.23
|
DNF
|
0.52, 4.00
|
0.63, 4.52
|
0.55, 3.70
|
0.65, 4.48
|
Vitamin K antagonistsd - Sulfamethoxazole/ trimethoprim
|
Bleeding
|
1.51 (2618)
|
1.37 (2387)
|
1.26 (2216)
|
1.21 (2127)
|
0.96
|
−19
|
1.40, 8.49
|
1.29, 9.00
|
1.22, 8.08
|
1.20, 8.20
|
Vitamin K antagonistsd - Metronidazole
|
Bleeding
|
0.42 (730)
|
0.39 (678)
|
0.44 (770)
|
0.45 (798)
|
0.54
|
DNF
|
0.39, 5.27
|
0.37, 4.70
|
0.42, 5.39
|
0.45, 5.77
|
Vitamin K antagonistsd - Ciprofloxacin
|
Bleeding
|
2.36 (4107)
|
2.37 (4152)
|
2.50 (4408)
|
2.09 (3681)
|
0.19
|
DNF
|
2.19, 7.45
|
2.24, 7.40
|
2.43, 8.09
|
2.07, 7.42
|
Narcotic analgesicsi - Benzodiazepinesj
|
Respiratory depression and sedation
|
101.23 (176057)
|
109.39 (191260)
|
112.79 (198647)
|
114.47 (201896)
|
0.91
|
+ 15
|
125.09, 27.06
|
127.73, 28.70
|
135.34, 30.64
|
137.90, 31.57
|
Verapamil - Beta-blockersk
|
Cardiovascular adverse effects (e.g. bradycardia)
|
6.14 (10677)
|
5.77 (10093)
|
5.45 (9593)
|
4.93 (8697)
|
0.98
|
−19
|
36.00, 3.22
|
38.03, 3.29
|
39.67, 3.32
|
39.18, 3.21
|
Carbamazepine - Clarithromycin
|
Carbamazepine toxicity, reduced clarithromycin effect
|
0.16 (274)
|
0.15 (256)
|
0.11 (199)
|
0.11 (197)
|
0.89
|
−28
|
0.54, 0.64
|
0.52, 0.57
|
0.43, 0.44
|
0.43, 0.56
|
Colchicine - Clarithromycin
|
Colchicine toxicity (e.g. pancytopenia)
|
0.00 (5)
|
0.00 (4)
|
0.02 (28)
|
0.01 (11)
|
LP
|
LP
|
0.10, 0.01
|
0.09, 0.01
|
0.61, 0.06
|
0.24, 0.03
|
Digoxin - Amiodarone
|
Digoxin toxicity
|
0.81 (1406)
|
0.75 (1318)
|
0.67 (1179)
|
0.49 (864)
|
0.92
|
−39
|
7.39, 12.67
|
7.82, 11.72
|
7.59, 10.44
|
6.27, 7.52
|
Digoxin - Verapamil
|
Digoxin toxicity
|
1.26 (2190)
|
1.10 (1927)
|
0.83 (1456)
|
0.64 (1121)
|
0.99
|
−49
|
11.51, 7.38
|
11.44, 7.26
|
9.37, 6.02
|
8.12, 5.05
|
HMG CoA reductase inhibitorsl - Ciclosporin
|
Statin toxicity (e.g. rhabdomyolysis)
|
0.08 (136)
|
0.08 (134)
|
0.10 (175)
|
0.08 (145)
|
0.22
|
DNF
|
0.03, 15.84
|
0.03, 15.50
|
0.04, 17.73
|
0.04, 14.10
|
Tamoxifen - CYP2D6 inhibitorsm
|
Reduced tamoxifen effect
|
0.04 (70)
|
0.02 (43)
|
0.03 (60)
|
0.01 (22)
|
LP
|
LP
|
5.63, 0.10
|
3.78, 0.06
|
4.71, 0.08
|
1.68, 0.03
|
|
Total
|
918.02 (1596613)
|
944.04 (1650576)
|
923.84 (1626745)
|
940.37 (1658416)
|
0.56
|
DNF
| | | | |