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Table 4 Prognostic effects of drugs in CHF patients with and without low GFR

From: Relationship between drug application and mortality rate in Chinese older coronary artery disease/chronic heart failure patients with and without low glomerular filtration rate

Drugs

Without low GFR

With low GFR

Survival time (days)

P value

P value

Survival time (days)

P value

P value

No use

Use

No use

Use

Beta-blockers

806 (652–959)

774 (686–863)

0.633

0.866

928 (705–1151)

603 (492–714)

0.742

0.885

ACEI/ARBs

791 (670–912)

805 (697–913)

0.370

0.911

634 (461–808)

702 (556–847)

0.125

0.426

Statins

581 (437–724)

889 (807–971)

< 0.001

< 0.001

681 (457–904)

639 (511–767)

0.203

0.641

Digoxin

890 (801–998)

691 (567–816)

0.004

0.519

652 (531–774)

626 (457–795)

0.037

0.095

  1. *Relationship of drugs with survival time was bivariately evaluated with Kaplan-Meier analysis; **relationship of drugs with mortality rate was multivariately adjusted by age, gender, body mass index, CAD, CHF, atrial fibrillation, hypertension, heart rate, systolic blood pressure, diastolic blood pressure, hemoglobin, albumin, glomerular filtration rate, fasting plasma glucose, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol using Cox Regression
  2. Abbreviations: ACEI/ARBs Renin-angiotensin-aldosterone system inhibitors/angiotensin receptor blockers, CAD Coronary artery disease, CHF Chronic heart failure, GFR Glomerular filtration rate
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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