Fig. 3

Effect of low-dose (LD, 2 mg/kg × 3) on initiating a syndrome. Occurrence of a syndrome was instrumentally detected with changes in EEG activity under the normal environmental conditions. A Representative samples of baseline (a) and the EEG responses to a first (b), second (c) and third injection (d). B X-axis represents time in hours, starting at 0 when given the first drug administration while y-axis represents % change in power spectral density (PSD) from baseline. MDMA caused a time-dependent reduction in power density: the first injection, F_(1,10) = 14.561, P = 0.0034; second injection, F_(1,10) = 52.313, P < 0.0001; third injection, F_(1,10) = 30.072, P = 0.0003. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the SAL control