Fig. 5
Effect of environment on the syndrome intensification. The syndrome intensity was estimated with changes in 5-HT (a) and EEG (b) under the modified environmental conditions. a Time-course of Tcor response to binge injection of HD (left panel) or LD MDMA (right). X-axis represents time in hours, starting at 0 when given the first drug administration while y-axis represents fold increases in 5-HT above baseline. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the SAL group at the same time point. **P < 0.01, indicating the first HD injection vs. the second or third HD injection. n.s., not significant, indicating the first LD injection vs. the second or third LD injection. b Time-course of EEG response to binge injection of HD (left panel) or LD MDMA (right). X-axis represents time in hours, starting at 0 as given the first drug administration while y-axis represents % change in power spectral density (PSD) from baseline. 10 mg/kg × 3, N = 4–6 rats/group; 2 mg/kg × 3, N = 4–6 rats/group. MDMA no longer caused a reduction in PSD (or desynchronization). Instead, there were increases in PSD (synchronization) under enriched environmental conditions