Fig. 6

Effects of MDMA doses and environments, respectively, on initiating and intensifying serotonergic injury. Tissue 5-HT content was used to estimate those effects. Data are expressed as an individual level (ng/mg wet tissue) for each treatment group (N = 4–6). a Changes in the FCx. b Changes in the hypothalamus. *P < 0.05 vs. the SAL group. CTL-S, saline as control; HD-H ^─, high-dose-induced hypothermia; HD-H⁺, high-dose-induced hyperthermia; LD-H ^─, low-dose-induced hypothermia; LD-H⁺, low-dose-induced hyperthermia