Fig. 2

Effect of topical gabapentin 10% gel (GBP-10%), topical control gel (CG) and systemic gabapentin at 75 mg/kg (GBP-75, i.p.) on the expression of cisplatin induced heat hypoalgesia [increased nociceptive response latency to heat stimulus in the hot-plate paradigm (paw withdrawal latency; PWL in s)] in bilateral hind paws after weekly intraperitoneal injection of cisplatin at 3.0 mg/kg (Cis-3) for four consecutive weeks. Each symbol represents the mean PWL in s ± SEM. ^#P < 0.05, ^###P < 0.001 as compared to the saline (Sal) treated controls, ^*P < 0.05, ^**P < 0.01, as compared to the cisplatin plus saline treated animal group, two-way repeated measures ANOVA followed by post hoc Bonferroni’s analysis; n = 6 rats per group