Fig. 4

Anti-hyperalgesic activities of poncirin in chronic inflammatory pain model induced by CFA (a) inhibition of acute mechanical hyperalgesia, (b) inhibition of acute mechanical allodynia, (c) inhibition of chronic mechanical hyperalgesia and (d) inhibition of chronic mechanical allodynia. Each data point represents the mean ± SEM of 6–7 mice per group. *p < 0.05, **p < 0.01 and ***p < 0.001 denote the significant differences from the negative control group