Table 1 Naranjo adverse drug reaction probability score
From: A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity
No. | Item | Yes | No | Do not know | Score |
|---|---|---|---|---|---|
1 | Are there previous conclusive reports of this reaction? | + 1 | 0 | 0 | + 1 |
2 | Did the adverse reaction event appear after the suspected drug was administered? | + 2 | −1 | 0 | + 2 |
3 | Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? | + 1 | 0 | 0 | + 1 |
4 | Did the adverse reaction reappear when the drug was readministered? | + 2 | −1 | 0 | + 2 |
5 | Are there alternative cause (other than the drug) that could on their own have caused the reaction? | −1 | + 2 | 0 | −1 |
6 | Did the reaction reappear when a placebo was given? | −1 | + 1 | 0 | 0 |
7 | Was the drug detected in the blood (or other fluids) in concentrations knows to be toxic? | + 1 | 0 | 0 | 0 |
8 | Was the reaction more severe when the dose was increased or less severe when the dose was decreased? | + 1 | 0 | 0 | 0 |
9 | Did the patient have a similar reaction to the same or similar drugs at any previous exposure? | + 1 | 0 | 0 | 0 |
10 | Was the adverse event confimed by any objective evidence? | + 1 | 0 | 0 | + 1 |
Total | 6 |