Fig. 3

Duration of KEA-1010 induced loss of righting reflex is shorter than ketamine. Probability of loss of righting reflex (LORR) following intravenous injection of KEA-1010 and ketamine over 30 s (a). ED₅₀ for LORR KEA-1010 is 11.4 mg/kg (95% CI 10.6 to 12.3); ED₅₀ for LORR ketamine (racemic) is 9.6 mg/kg (95% CI 8.5–10.9). Duration of LORR following intravenous injection of KEA-1010 and ketamine over 30 s (b). Slope of LORR duration is KEA 1010 17.0 s/mg/kg (95% CI 12.6 to 21.4); ketamine 69.8 s/mg/kg (95% CI 45.1 to 94.5). Duration of LORR following KEA-1010 and ketamine via intravenous bolus (c) and 10 minute infusion (d) at hypnotic dosing in rats. Duration of LORR on day 1 (e) and day 6 (f) following intravenous bolus injection of KEA-1010 and ketamine in rats receiving either saline, or morphine, via subcutaneous minipump. Data: mean (SEM). **P < 0.01 (Students T testing). N = 43 (Total)