Fig. 4

KEA-1010 attenuates thermal nocifensive behaviour. Tail flick latency testing following hypnotic bolus [KEA-1010 11 mg/kg; ketamine 10 mg/kg] (a), sub-hypnotic bolus [KEA-1010 5.5 mg/kg; ketamine 5 mg/kg] (b), 10 minute hypnotic infusion [KEA-1010 56 mg/kg; ketamine 28 mg/kg] (c), and 10-minute sub-hypnotic infusion [KEA-1010 40 mg/kg; ketamine 20 mg/kg] (d) in rats. Shaded area denotes duration of drug administration. Data: mean (SEM). *P < 0.05 (KEA-1010 vs. Ketamine; Bonferroni). N = 5 all groups