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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

Fig. 7

Effectiveness of KEA-1010-induced thermal antinociception in morphine treated rats. Injection of KEA 1010 and ketamine prolonged tail flick latency on day one (a) and day six (b) in saline minipump rats. KEA-1010 augmented opioid induced analgesic responses in rats receiving morphine via minipump on day one (c). KEA remained effective in tail flick prolongation following development of opioid tolerance on day six (d). Data mean (SEM). #P < 0.05, ##P < 0.01, ###P < 0.001 (KEA-1010 vs. saline); *P < 0.05, **P < 0.01, ***P < 0.001 (ketamine vs. saline; Bonferroni). N = 6 all groups

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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