Table 2 The Intra- and Inter-day precision and accuracy (n = 6), extraction recovery (n = 6) for parecoxib, valdecoxib and celecoxib (IS) in rat plasma
Compound | Concentration (ng/mL) | Intra-day | Inter-day | Recovery | |||
|---|---|---|---|---|---|---|---|
Precision (RSD%) | Accuracy (RE%) | Precision (RSD%) | Accuracy (RE%) | Mean + SD (%) | RSD (%) | ||
100 | 8.3 | 4.3 | 11.5 | 10.5 | 87.0 ± 1.8 | 2 | |
Parecoxib | 800 | 10.5 | −3.2 | 13.9 | 6.6 | 79.0 ± 5.0 | 6.4 |
8000 | 5.6 | 6 | 11.4 | −7 | 87.1 ± 0.4 | 0.5 | |
5 | 9.5 | 5.6 | 14 | −5.6 | 114.6 ± 8.4 | 7.3 | |
Valdecoxib | 40 | 7.3 | 1.2 | 7.1 | 14.8 | 79.3 ± 1.1 | 1.4 |
400 | 4.9 | 2.9 | 7.5 | 6.4 | 70.0 ± 1.4 | 2.0 | |
Celecoxib | 200 | 3.8 | 7.3 | 4.8 | 8 | 79.5 ± 2.0 | 2.6 |