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Table 5 Relationship between treatment duration and laboratory parameters

From: Comparative effect of dipeptidyl-peptidase 4 inhibitors on laboratory parameters in patients with diabetes mellitus

Laboratory parametersDrugsTime pointNUnadjustedp-valueaAdjustedp-value
LS Mean (95%CI)LS Mean (95%CI)
HbA1c (%)Sitagliptin   <.0001 <.0001
baseline8797.8 (7.7, 7.9)reference7.8 (7.8, 7.9)reference
0-3 M8357.4 (7.3, 7.4)*7.4 (7.3, 7.5)*
3-12 M2087.2 (7, 7.3)*7.2 (7.1, 7.3)*
Vildagliptin   <.0001 <.0001
baseline2537.8 (7.6, 7.9)reference7.7 (7.6, 7.9)reference
0-3 M2417.2 (7, 7.3)*7.1 (7, 7.3)*
3-12 M647.1 (6.9, 7.3)*7 (6.8, 7.2)*
Teneligliptin   <.0001 <.0001
baseline2607.8 (7.7, 8)reference7.9 (7.7, 8)reference
0-3 M2377.2 (7.1, 7.4)*7.2 (7.1, 7.4)*
3-12 M956.9 (6.7, 7.1)*6.9 (6.7, 7.1)*
Alogliptin   <.0001 <.0001
baseline2377.4 (7.3, 7.5)reference7.4 (7.3, 7.6)reference
0-3 M2167 (6.8, 7.1)*7 (6.9, 7.1)*
3-12 M616.8 (6.6, 7)*6.8 (6.6, 7)*
Linagliptin   <.0001 <.0001
baseline1807.4 (7.3, 7.6)reference7.4 (7.3, 7.6)reference
0-3 M1767 (6.8, 7.1)*6.9 (6.8, 7.1)*
3-12 M586.8 (6.6, 7)*6.8 (6.6, 7)*
creatinine (mg/dL)Sitagliptin   <.0001 <.0001
baseline8310.8 (0.78, 0.82)reference0.76 (0.75, 0.78)reference
0-3 M7950.82 (0.8, 0.84)*0.79 (0.77, 0.8)*
3-12 M1980.86 (0.83, 0.88)*0.82 (0.8, 0.85)*
Vildagliptin   0.035 0.0375
baseline2330.89 (0.84, 0.94)reference0.84 (0.79, 0.89)reference
0-3 M2220.91 (0.86, 0.97) 0.87 (0.81, 0.92) 
3-12 M600.93 (0.87, 0.99) 0.88 (0.82, 0.94) 
Teneligliptin   <.0001 <.0001
baseline2590.94 (0.88, 1)reference0.88 (0.82, 0.94)reference
0-3 M2390.98 (0.91, 1.04)*0.92 (0.86, 0.98)*
3-12 M981.05 (0.98, 1.12)*0.99 (0.92, 1.06)*
Alogliptin   0.0001 0.0001
baseline2260.82 (0.79, 0.86)reference0.77 (0.74, 0.8)reference
0-3 M2050.85 (0.82, 0.88)*0.8 (0.77, 0.83)*
3-12 M620.86 (0.82, 0.9)*0.81 (0.77, 0.85)*
Linagliptin   0.002 0.0021
baseline1741.04 (0.95, 1.12)reference0.99 (0.91, 1.08)reference
0-3 M1691.08 (1, 1.16)*1.03 (0.95, 1.12)*
3-12 M581.12 (1.03, 1.21)*1.07 (0.98, 1.17)*
eGFR (mL/min/1.73m2)Sitagliptin   <.0001 <.0001
baseline83174 (72.7, 75.4)reference74.4 (73.2, 75.5)reference
0-3 M79572.1 (70.8, 73.5)*72.4 (71.3, 73.6)*
3-12 M19870 (68.3, 71.7)*70.4 (68.8, 71.9)*
Vildagliptin   <.0001 <.0001
baseline23370.3 (67.3, 73.3)reference70.6 (67.7, 73.6)reference
0-3 M22267.5 (64.5, 70.6)*67.8 (64.9, 70.8)*
3-12 M6069 (65.6, 72.4) 69.3 (66, 72.7) 
Teneligliptin   <.0001 <.0001
baseline25966.3 (63.6, 69)reference67 (64.4, 69.5)reference
0-3 M23963.6 (60.8, 66.3)*64.2 (61.7, 66.8)*
3-12 M9863 (60, 66)*63.7 (60.8, 66.5)*
Alogliptin   0.0009 0.0009
baseline22672.5 (70, 75)reference73.2 (70.8, 75.7)reference
0-3 M20570.6 (68, 73.1)*71.3 (68.8, 73.8)*
3-12 M6270.4 (67.5, 73.3) 71.2 (68.3, 74.1) 
Linagliptin   0.001 0.001
baseline17461.8 (58, 65.7)reference62.2 (58.3, 66.1)reference
0-3 M16959.8 (56, 63.7)*60.2 (56.3, 64.1)*
3-12 M5859.5 (55.4, 63.6)*59.9 (55.7, 64)*
HDL (mg/dL)Sitagliptin   0.0037 0.0033
baseline72651.3 (50.3, 52.3)reference52.2 (51.2, 53.2)reference
0-3 M68550.5 (49.4, 51.5)*51.4 (50.3, 52.4)*
3-12 M14150 (48.6, 51.5) 50.9 (49.5, 52.3)*
Vildagliptin   0.0007 0.0008
baseline20347.3 (45.6, 49)reference48.6 (46.9, 50.3)reference
0-3 M19446.1 (44.4, 47.8)*47.4 (45.7, 49.1)*
3-12 M5044.5 (42.3, 46.6)*45.8 (43.7, 48)*
Teneligliptin   0.427 0.4293
baseline21250.1 (48.3, 52)reference51.8 (49.9, 53.6)reference
0-3 M18850.2 (48.4, 52.1) 51.8 (50, 53.7) 
3-12 M7849.3 (47.1, 51.4) 50.9 (48.7, 53) 
Alogliptin   0.5739 0.5798
baseline18347.5 (45.6, 49.5)reference48.6 (46.5, 50.7)reference
0-3 M16347.1 (45.1, 49) 48.1 (46, 50.2) 
3-12 M4746.7 (44.2, 49.3) 47.8 (45.1, 50.4) 
Linagliptin   0.3891 0.3894
baseline14448.9 (46.8, 51)reference49.7 (47.5, 51.9)reference
0-3 M14048.3 (46.2, 50.4) 49.1 (46.9, 51.3) 
3-12 M4349.7 (47, 52.3) 50.4 (47.7, 53.2) 
TC (mg/dL)Sitagliptin   0.0004 0.0004
baseline728192.3 (189.8, 194.8)reference194 (191.5, 196.5)reference
0-3 M682188.9 (186.3, 191.4)*190.6 (188, 193.2)*
3-12 M161194.3 (190.4, 198.3) 196 (192.1, 200) 
Vildagliptin   0.0071 0.0024
baseline204188.7 (183.6, 193.8)reference190.9 (185.6, 196.2)reference
0-3 M194183.4 (178.2, 188.6)*185.5 (180.2, 190.9)*
3-12 M50183.7 (176.5, 190.9) 186 (178.7, 193.4) 
Teneligliptin   0.0668 0.0764
baseline217190.1 (185.2, 195)reference193.6 (188.7, 198.5)reference
0-3 M196186.5 (181.5, 191.5) 189.9 (184.9, 194.9) 
3-12 M76185 (178.5, 191.4) 188.9 (182.4, 195.3) 
Alogliptin   0.043* 0.0372
baseline176188 (182.5, 193.5)reference189.5 (183.6, 195.4)reference
0-3 M153183.4 (177.8, 189)*184.8 (178.8, 190.8)*
3-12 M48188.4 (180.9, 195.9) 190.1 (182.3, 197.9) 
Linagliptin   0.1222 0.1105
baseline151189.3 (183.1, 195.5)reference191.6 (185.2, 198) 
0-3 M146186.3 (180.1, 192.5) 188.6 (182.2, 195) 
3-12 M50191.4 (183.8, 198.9) 193.8 (186.1, 201.6) 
TG (mg/dL)Sitagliptin   0.0473 0.0469
baseline755145.1 (139.4, 150.7)reference142.9 (137.1, 148.8)reference
0-3 M712139.1 (133.3, 144.8)*136.9 (131, 142.8)*
3-12 M160141.9 (132.4, 151.4) 140 (130.4, 149.6) 
Vildagliptin   0.0203 0.0072
baseline206160.3 (148.9, 171.7)reference190.9 (185.6, 196.2)reference
0-3 M195148.2 (136.6, 159.7)*185.5 (180.2, 190.9)*
3-12 M54144.4 (126.8, 162) 186 (178.7, 193.4) 
Teneligliptin   0.1054 0.1204
baseline233151.3 (140.7, 161.9)reference149.4 (138.6, 160.3)reference
0-3 M209145.2 (134.2, 156.1) 143.1 (132, 154.3) 
3-12 M85136.4 (121.3, 151.4) 135.2 (120, 150.4) 
Alogliptin   0.0086 0.0077
baseline197155 (143.6, 166.3)reference155.3 (143.1, 167.5)reference
0-3 M174140.3 (128.6, 152)*140.5 (128, 153)*
3-12 M51152.2 (135, 169.5) 153 (135.1, 170.9) 
Linagliptin   0.9511 0.9521
baseline159146.2 (134, 158.5)reference146.8 (134, 159.6)reference
0-3 M154144.5 (132.2, 156.9) 145.1 (132.1, 158) 
3-12 M49144.6 (126.1, 163) 145.4 (126.5, 164.4) 
AST (U/L)Sitagliptin   0.0879 0.0856
baseline83027.8 (26.6, 29)reference27.5 (26.3, 28.7)reference
0-3 M79426.8 (25.6, 28.1) 26.5 (25.3, 27.8) 
3-12 M19928 (26.2, 29.8) 27.7 (25.9, 29.5) 
Vildagliptin   0.3947 0.3942
baseline23230.3 (27.1, 33.5)reference30.5 (27.1, 33.9)reference
0-3 M22231.2 (28, 34.4) 31.4 (28, 34.8) 
3-12 M5732.6 (28.2, 37) 32.8 (28.2, 37.4) 
Teneligliptin   0.7444 0.7366
baseline25629.8 (26.9, 32.8)reference30.6 (27.5, 33.6)reference
0-3 M23628.5 (25.5, 31.6) 29.2 (26.1, 32.4) 
3-12 M9729.4 (24.9, 33.9) 30.2 (25.7, 34.8) 
Alogliptin   0.0056 0.0056
baseline22129.9 (27.3, 32.4)reference29.5 (26.7, 32.3)Reference
0-3 M20026.8 (24.2, 29.4)*26.4 (23.6, 29.2)*
3-12 M6128.4 (24.8, 32) 28 (24.3, 31.8) 
Linagliptin   0.3101 0.3365
baseline17624.7 (22.7, 26.7)reference25.1 (23.1, 27.1)reference
0-3 M17124.2 (22.2, 26.2) 24.6 (22.6, 26.7) 
3-12 M5823.3 (20.9, 25.7) 23.8 (21.3, 26.3) 
ALT (U/L)Sitagliptin   <.0001 <.0001
baseline83030.4 (28.8, 32)reference29.8 (28.3, 31.4)reference
0-3 M79428.1 (26.5, 29.7)*27.5 (25.9, 29.1)*
3-12 M19927.8 (25.5, 30.1)*27.2 (25, 29.5)*
Vildagliptin   0.1288 0.1286
baseline23332.3 (29.1, 35.6)reference32 (28.7, 35.2)reference
0-3 M22330.2 (27, 33.5) 29.8 (26.5, 33.2) 
3-12 M5831.6 (27.2, 36) 31.1 (26.7, 35.6) 
Teneligliptin   0.0824 0.089
baseline25630.2 (27, 33.4)reference30.6 (27.3, 33.9)reference
0-3 M23627.5 (24.2, 30.8) 27.9 (24.5, 31.3) 
3-12 M9725.5 (20.9, 30.2) 26 (21.3, 30.8) 
Alogliptin   <.0001 <.0001
baseline22334.7 (31.1, 38.3)reference34.1 (30.3, 37.9)reference
0-3 M20229 (25.4, 32.6)*28.4 (24.5, 32.2)*
3-12 M6129.6 (24.8, 34.5)*29.1 (24, 34.1)*
Linagliptin   <.0001 <.0001
baseline17626.2 (22.6, 29.8)reference26.5 (23.2, 29.9)reference
0-3 M17123.4 (19.8, 26.9)*23.7 (20.3, 27.1)*
3-12 M5822.4 (18.4, 26.3)*22.8 (19, 26.6)*
  1. *p < 0.05 (compared with baseline period, multiple-comparison test: Dunnett’s post-hoc analysis), aAdjusted for age and sex
  2. LS mean least square mean, CI confidence interval, HbA1c hemoglobin A1c, eGFR estimated glomerular filtration rate, HDL high density lipoprotein, TC total cholesterol, TG triglyceride, AST aspartate aminotransferase, ALT alanine aminotransferase