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Table 4 Ten most frequent drug-reaction pairs according to age group

From: Characteristics of pediatric adverse drug reaction reports in the Japanese Adverse Drug Event Report Database

Generic nameReactionn (%)
a. < 10 years
 OseltamivirAbnormal behavior257 (0.8)
 Rurioctocog alfa pegol
(Genetical recombination)
Factor VIII inhibition102 (0.3)
 ZanamivirAbnormal behavior82 (0.3)
 CyclosporinePosterior reversible encephalopathy syndrome71 (0.2)
 TheophyllineSeizure53 (0.2)
 AcetaminophenToxic epidermal necrolysis52 (0.2)
 TheophyllineEncephalopathy50 (0.2)
 OseltamivirSeizure48 (0.2)
 AcetaminophenStevens-Johnson syndrome44 (0.1)
 AmoxicillinErythema multiforme44 (0.1)
b. 10–19 years
 ZanamivirAbnormal behavior216 (0.8)
 OseltamivirAbnormal behavior142 (0.5)
 CarbamazepineDrug reaction with eosinophilia and systemic symptoms59 (0.2)
 ZanamivirHallucination59 (0.2)
 L-AsparaginasePancreatitis acute46 (0.2)
 CyclosporineNephropathy toxic42 (0.2)
 Irradiated platelet concentrate,
leukocytes reduced
Anaphylactic reaction38 (0.1)
 LamotrigineRash38 (0.1)
 LevetiracetamEpilepsy37 (0.1)
 VincristineNeutropenia37 (0.1)