Table 4 Ten most frequent drug-reaction pairs according to age group
Generic name | Reaction | n (%) |
|---|---|---|
a. < 10 years | ||
Oseltamivir | Abnormal behavior | 257 (0.8) |
Rurioctocog alfa pegol (Genetical recombination) | Factor VIII inhibition | 102 (0.3) |
Zanamivir | Abnormal behavior | 82 (0.3) |
Cyclosporine | Posterior reversible encephalopathy syndrome | 71 (0.2) |
Theophylline | Seizure | 53 (0.2) |
Acetaminophen | Toxic epidermal necrolysis | 52 (0.2) |
Theophylline | Encephalopathy | 50 (0.2) |
Oseltamivir | Seizure | 48 (0.2) |
Acetaminophen | Stevens-Johnson syndrome | 44 (0.1) |
Amoxicillin | Erythema multiforme | 44 (0.1) |
b. 10–19 years | ||
Zanamivir | Abnormal behavior | 216 (0.8) |
Oseltamivir | Abnormal behavior | 142 (0.5) |
Carbamazepine | Drug reaction with eosinophilia and systemic symptoms | 59 (0.2) |
Zanamivir | Hallucination | 59 (0.2) |
L-Asparaginase | Pancreatitis acute | 46 (0.2) |
Cyclosporine | Nephropathy toxic | 42 (0.2) |
Irradiated platelet concentrate, leukocytes reduced | Anaphylactic reaction | 38 (0.1) |
Lamotrigine | Rash | 38 (0.1) |
Levetiracetam | Epilepsy | 37 (0.1) |
Vincristine | Neutropenia | 37 (0.1) |