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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: 18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice

Fig. 5

GA treatment inhibited PI3K-Akt activation in HaCaT keratinocytes. (A) HaCaT keratinocytes were seeded into 6-well plates and treated with GA (40 μM) and/or NAC (5 mM) for 24 h. Akt and p-Akt protein levels were detected by Western blotting. β-actin served as an internal reference. *P < 0.05. (B) HaCaT keratinocytes were seeded into 96-well plates and treated with different doses of LY294002 for 24 h. Cell viability was measured using CCK-8 assay. **P < 0.01 and ***P < 0.001 vs. control (Ctl) group. (C) HaCaT keratinocytes were seeded into 96-well plates and treated with GA (20, 40 and 80 μM) and/or LY294002 (20 μM) for 24 h. Cell viability was measured using CCK-8 assay. *P < 0.05. **P < 0.01

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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