Table 3 Pharmacokinetic parameters and ratios based on geometric least squares means
From: Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Treatment group | |||
|---|---|---|---|
Study 1 | Esaxerenone (n = 22) | + Amlodipine (n = 22) | Ratio (90% CI) |
Cmax, ng/mL | 35.0 | 33.5 | 0.958 (0.905, 1.015) |
AUClast, ng·h/mL | 551 | 635 | 1.154 (1.118, 1.190) |
AUCinf, ng·h/mL | 565 | 663 | 1.173 (1.136, 1.212) |
Study 2 | Amlodipine (n = 18) | + Esaxerenone (n = 18) | Ratio (90% CI) |
Cmax, ng/mL | 2.04 | 2.24 | 1.099 (1.059, 1.140) |
AUClast, ng·h/mL | 84.4 | 100 | 1.185 (1.132, 1.240) |
AUCinf, ng·h/mL | 97.6 | 118 | 1.214 (1.157, 1.273) |
Study 3 | Digoxin (n = 19) | + Esaxerenone (n = 19) | Ratio (90% CI) |
Cmax, ng/mL | 1.47 | 1.66 | 1.130 (0.998, 1.280) |
Ctrough, ng/mL | 0.526 | 0.572 | 1.088 (1.033, 1.145) |
AUCtau, ng·h/mL | 15.1 | 16.2 | 1.072 (1.015, 1.133) |