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Table 3 Pharmacokinetic parameters and ratios based on geometric least squares means

From: Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

  Treatment group  
Study 1 Esaxerenone (n = 22) + Amlodipine (n = 22) Ratio (90% CI)
Cmax, ng/mL 35.0 33.5 0.958 (0.905, 1.015)
AUClast, ng·h/mL 551 635 1.154 (1.118, 1.190)
AUCinf, ng·h/mL 565 663 1.173 (1.136, 1.212)
Study 2 Amlodipine (n = 18) + Esaxerenone (n = 18) Ratio (90% CI)
Cmax, ng/mL 2.04 2.24 1.099 (1.059, 1.140)
AUClast, ng·h/mL 84.4 100 1.185 (1.132, 1.240)
AUCinf, ng·h/mL 97.6 118 1.214 (1.157, 1.273)
Study 3 Digoxin (n = 19) + Esaxerenone (n = 19) Ratio (90% CI)
Cmax, ng/mL 1.47 1.66 1.130 (0.998, 1.280)
Ctrough, ng/mL 0.526 0.572 1.088 (1.033, 1.145)
AUCtau, ng·h/mL 15.1 16.2 1.072 (1.015, 1.133)
  1. AUCinf area under the plasma concentration–time curve up to infinity, AUClast AUC up to the last quantifiable time, AUCtau AUC over the dosing interval, CI confidence interval, Cmax peak plasma concentration, Ctrough trough plasma concentration