Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Table 1 Physiological and biological input parameters for PK-Sim Simulation

Parameters/Properties		Values used	Reference values	References
Physicochemical	Lipophilicity (Log P)	-1.22	-1.22	[36]
	Plasma protein binding	Does not bind		[37]
	Molecular weight	405.48g/mol		[38]
	Pka	2.5	2.5 (at pH 7)	[36]
	Solubility (mg/L) at reference pH	97000	97000	[39].
Biological	Renal clearance	0.56 ml/min/kg	47±8.3ml/min 2.82±0.0083L/h	[40]
	Metabolism	-	No metabolism	[30]
	Elimination	Renal route	Renal route	[30]

ISSN: 2050-6511