Ethnicity | Protocol | Dose OD (mg) | Cmax (ng/ml) | Tmax (h) | AUC0-t (ng.h/ml) | References | |||
---|---|---|---|---|---|---|---|---|---|
Observed | Predicted (Mean) | Observed | Predicted (Mean) | Observed | Predicted Min-Max | ||||
European | IV dose | 2.97 | ā | 182.3 | ā | 0.1 | 682Ā Ā±Ā 156a | 403ā848.9 | [41] |
5.53 | ā | 347.2 | ā | 0.1 | 1026Ā Ā±Ā 123a | 753.9ā1598 | Ā | ||
11.2 | Ā | 707 | Ā | 0.1 | 1884Ā Ā±Ā 107a | 1453ā3100 | Ā | ||
Caucasians | Oral (Fasting) | 20 | 86āĀ±ā48 | 65.52 | 6.2āĀ±ā1.1 | 6.15 | 1231Ā Ā±Ā 620b | 495ā2097.6 | [42] |
Oral (Fed) | 20 | 69āĀ±ā19 | 58.9 | 6.8āĀ±ā1 | 7.6 | 1029Ā Ā±Ā 254b | 525ā2124.7 | Ā | |
European | Oral (Fasting) | 20 | 79.8āĀ±ā39.4 | 69.32 | 6.5āĀ±ā1.7 | 5.6 | 992.8Ā Ā±Ā 520a | 556.7ā2298 | [26] |