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Table 3 Predicted pharmacokinetic parameters of lisinopril after IV and oral dose administration

From: Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Ethnicity Protocol Dose
OD
(mg)
Cmax (ng/ml) Tmax (h) AUC0-t (ng.h/ml) References
Observed Predicted
(Mean)
Observed Predicted
(Mean)
Observed Predicted
Min-Max
European IV dose 2.97 182.3 0.1 682 ± 156a 403–848.9 [41]
5.53 347.2 0.1 1026 ± 123a 753.9–1598  
11.2   707   0.1 1884 ± 107a 1453–3100  
Caucasians Oral (Fasting) 20 86 ± 48 65.52 6.2 ± 1.1 6.15 1231 ± 620b 495–2097.6 [42]
Oral (Fed) 20 69 ± 19 58.9 6.8 ± 1 7.6 1029 ± 254b 525–2124.7  
European Oral (Fasting) 20 79.8 ± 39.4 69.32 6.5 ± 1.7 5.6 992.8 ± 520a 556.7–2298 [26]
  1. AUC0-ta: Area under the curve from time zero to 72 h
  2. AUC0-tb: Area under the curve from time zero to 120 h