Skip to main content

Table 2 The percent of clinical effects in methadone alone poisoning and co-ingestion

From: Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010–2017

Variable Total Single exposure of methadone (n = 354) Co exposure of Methadone with other drugs (n = 619)
Coma/CNS 472 (48.6%) 354 (100%) 118 (19.1%)
Agitation 69 (7.1%) 39 (11.1%) 30 (4.84%)
Seizures 21 (2.2%) 13 (3.67%) 8 (1.29%)
Weakness 6 (0.6%) 2 (0.56%) 4 (0.64%)
pH < 7 57 (5.8%) 43 (12/0%) 14 (2.26%)
Bradycardia 41 (4.2%) 26 (7.28%) 15 (2.42%)
Hypertension 34 (3.5%) 24 (6.72%) 10 (16.1%)
Hypotension 38 (3.9%) 28 (7.91%) 10 (16.1%)
Tachycardia 22 (2.3%) 13 (3.67%) 9 (1.45%)
QTc > 500 milliseconds 24 (2.9%) 20 (5.64%) 4 (0.64%)
Acute Kidney injury 92 (9.5%) 70 (19.7%) 22 (3.55%)
Rhabdomyolysis 43 (4.4%) 35 (9.88%) 8 (1.29%)
Aspiration pneumonitis 53 (5.4%) 44 (12.4%) 9 (1.45%)
Respiratory depression 327 (33.6%) 251 (70.9%) 76 (12.3%)
Hepatotoxicity (AST > 1000) 36 (3.7%) 28 (7.91%) 8 (1.29%)
  1. Values are frequency and percentage
  2. The percentages in the methadone only and methadone plus coingestants are calculated in each group
  3. Abbreviations: AST aspartate aminotransferase, CNS central nervous system