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Table 3 Comparison of methadone doses and effect rates in patients with single or co-ingestant exposure of methadone

From: Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010–2017

Complications Dose of methadone in methadone alone (mg) Dose of methadone in methadone plus other drugs (mg)
Coma/Central nervous system (CNS) depression Yes 96.2 [56.8–125.0] 97.2 [72.3–136.0]
No 65.9 [38.6–84.1] 124.3 [100.1–168.7]
Agitation Yes 132.5 [98.3–140.7] 119.3 [108.9–127.1]
No 125.0 [96.2–156.4] 37.5 [29.8–65.3]
No 66.6 [54.8–89.2] 121.3 [95.6–163.8]
Seizures Yes 138.2 [96.5–165.1] 136.9 [103.6–172.3]
No 145.2 [100.2–189.0] 120.1 [89.6–160.3]
Weakness Yes 43.7 [35.6–57.6] 43.6 [32.1–68.9]
No 14.2 [9.6–25.6] 119.6 [100.0–156.3]
pH < 7 Yes 40.2 [24.3–50.8] 45 ± 24.2
No 69.8 [57.3–99.2] 124.3 [100.6–154.9]
Bradycardia Yes 42.3 [36.8–60.2] 64.5 [49.6–87.0]
No 38.6 [30.1–45.7] 119.9 [96.3–157.6]
Hypertension Yes 40.2 [32.3–50.9] 126.3 [100.5–160.0]
No 39.6 [28.9–61.2] 120.3 [95.6–156.8]
Hypotension Yes 32.0 [25.3–41.9] 26.3 [14.6–38.9]
No 40.9 [32.9–53.6] 126.5 [105.3–153.6]
Tachycardia Yes 74.9 [62.3–90.4] 147.1 [125.3–175.1]
No 36.0 [28.9–51.4] 123.6 [98.0–168.6]
QTc > 500 milliseconds Yes 74.2 [52.8–88.6] 32.1 [29.6–36.5]
No 34.5 [28.6–58.9] 128.7 [106.5–150.6]
Acute Kidney injury Yes 42.5 [14.8–65.3] 16.8 [9.8–26.1]
No 117.3 [84.0–140.4] 102.3 [86.7–123.9]
Rhabdomyolysis Yes 37.5 [29.7–50.0] 42.3 [19.0–57.8]
No 43.8 [34.6–59.9] 124.3 [97.8–150.1]
Aspiration pneumonitis Yes 24.6 [16.7–36.8] 37.8 [26.3–49.0]
No 28.6 [14.6–34.5] 124.8 [100.1–148.6]
Respiratory depression Yes 80.3 [60.3–100.2] 46.6 [34.8–67.2]
No 128.7 [100.2–168.7] 108.9 [85.3–125.6]
Hepatotoxicity (AST > 1000) Yes 45.2 [25.6–59.9] 43.2 [29.7–60.0]
No 62.4 [48.7–81.0] 122.3 [99.3–145.6]
  1. Dose values are mean ± Standard deviation
  2. *: Mann-Whitney test
  3. z = test statistics Mann-Whitney