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Table 1 Effect of curcumin on the levels of MDA, GSH, SOD and GSH-Px in cerebral homogenates prepared from ACR intoxicated rats (n = 10, mean ± SD)

From: The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

Groups

MDA

(nmol/mg prot)

GSH

(mg/g prot)

SOD

(U/mg prot)

GSH-Px

(U/mg prot)

Normal

0.425 ± 0.141

4.41 ± 0.58

60.21 ± 5.38

14.81 ± 1.95

ACR

1.133 ± 0.352 **

2.30 ± 0.47**

52.72 ± 6.94 **

10.36 ± 1.84 **

ACR + curcumin 50 mg/kg

0.918 ± 0.322

2.77 ± 0.46 #

53.89 ± 8.02

12.58 ± 1.96 #

ACR + curcumin 100 mg/kg

0.854 ± 0.216 #

2.92 ± 0.59 #

59.16 ± 6.46 #

13.15 ± 1.87 ##

  1. **P < 0.01 compared to the corresponding control rats. # P < 0.05, ## P < 0.01; compared with the corresponding ACR group
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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