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Table 3 Studies of the prevalence of potential DDIs in included articles

From: Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies

Region Author Pathology Target population Study setting No. of patients No. of patients with DDIs Prevalence patients with DDIs (%) No. of potential DDIs
Major Moderate Minor Unknown& Contraindication
Oromia Gunasekaran et al., 2016 [25] All All hospitalized patients All wards 300 267 89.00 62 (23.2%) 95 (35.58%) 110 (41.2%)  
Behailu Terefe Tesfaye et al., 2017 [6] HIV/AIDS All HIV infected patients ART Clinic 350 350 100.00 2 (0.08%) 1767 (72.69%) 662 (27.2%)  
Diksis et al., 2019 [5] Cardiac disorder Cardiac adult patients Medical ward 200 195 97.50 316 (32.7%) 441 (45.6%) 210 (21.7%)  
Chelkeba L et al., 2013 [26] Cardiac disorder Patients on CV medication in OPD Cardiac clinic 322 297 92.24 88 (29.6%) 200 (67.34%) 9 (3.03%)  
Amhara B.Akshaya Srikanth et al., 2014 [27] All All hospitalized patients Medical ward 100 78 78.00 53 (12.8%) 253 (61.26%) 107 (25.9%)  
Admassie, et al., 2013 [28] All All hospitalized patients Inpatients and Out patient 2180 711 32.61 127 (9.59%) 1020 (77.04%) 177 (13.4%) Contraindication = 11 (0.83%)
Henok Getachew et al., 2016 [29] All All hospitalized pediatric patients Pediatric ward 384 176 45.83 40 (10.2%) 201 (51.15%) 152 (38.7%)  
Tigray Teka et al., 2016 [30] All All hospitalized elder patients Medical ward 140 87 62.14 46 (51.6%) 36 (43.9%) 0 (0.0%) Contraindication = 5 (6.1%)
Zeru Gebretsadik et al., 2017 [31] All All patients who come for medical service Outpatient pharmacy 596 275 46.14 34 (110.3%) 210 (63.444%) 87 (26.3%) unknown = 22 (6.65%)
Haftay Berhane Mezgebe, 2015 [7] Psychiatric illness Patients with psychiatric illness Psychiatric unit 216 176 81.48 198 (43.8%) 232 (51.33%) 22 (4.87%) Contraindication = 13 (2.88%)
Teklay et al., 2014 [32] DVT Patients on warfarin therapy Medical ward 133 132 99.25 11,827.6(%) 310 (72.43%) 0 (0.00%)  
Yesuf TA, et al., 2017 [33] All All hospitalized patients Medical ward 204 135 53.43 150 (80.6%) 36 (19.35%) 0 (0.00%) Contraindication = 80 (43%)
Addis Ababa Tesfaye and Nedi, 2017 [34] All All hospitalized patients Medical ward 252 197 78.17 94 (13.1%) 385 (53.55%) 240 (33.4%)  
Kibrom et al., 2018 [35] All Adult patients Medical ward 384 209 54.43 105 (35.7%) 157 (53.4%) 32 (10.9%) Contraindication = 2 (0.68%)
  1. Abbreviations: HIV Human Immune Deficiency Virus, AIDS Acquire Immune Deficiency Syndrome, ART Antiretroviral Therapy, CV Cardio Vascular, OPD Outpatient Department