Table 2 Molecular docking of continentalic acid with various protein targets
Proteins | PDB ID | Amino Acid | Binding energies (kcal\mol) |
|---|---|---|---|
Keap 1 | 4iqk | VAL465 | −9.0 |
Nrf2 | 2flu | PHE93 | −8.4 |
P65 | 1vkx | ALA497 | −7.2 |
HO-1 | 1ubb | HIS25 | −6.5 |
TNF-α | 2az5 | TYR59 | −8.2 |
IL-1β | 1itb | GLU202 | −6.5 |
IL-6 | 1p9m | THR130 | −6.5 |
COX-2 | 5iqk | PRO543 | −7.5 |