N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test

Table 1 Paw latency period on hot plate test in the experimental groups (n= 8 in each group)

	Control	APAP	NAC	AN 200	AN 400	AN 600	Effect size	CI (95%)
Baseline	9.83 ±1.8	8.27 ±1.1	9.2 ±1.6	8.48 ±1.18	8.6±1.5	8.88±1.89	0.01	0.08–0.15
30 min	9.13±1.92	12.37±2.01^a	10.50±2.24^b	12.76±1.77^ac	14.46±1.69^ac	16.40±1.53^abcd	0.65	0.55–0.78
60 min	9.18±1.71	14.58±1.68^a	13.11±1.83^a	14.59±1.57^a	17.45±2.36^abcd	18.79±3.35^abcd	0.70	0.67–0.75
90 min	9.04±1.67	16.95±1.91^a	14.20±2.29^a	17.2±2.26^a	19.49±2.85^abc	22.91±5.19^abcd	0.71	0.67–0.79

The analgesic effect of acetaminophen (APAP), N-acetylcysteine (NAC) and simultaneous feeding of acetaminophen (300 mg/kg) with the dosage of 200–600 mg/kg of NAC and comparing that with the control group in rats. There were 8 Sprague-Dawley rats in each group. Delay periods in the all groups were analyzed through the one-way ANOVA test followed by the Bonferroni post hoc test. The data have been reported by mean± standard deviation
^asignificant difference with the control group
^bsignificant difference in comparison with APAP
^csignificant difference in comparison with NAC
^dsignificant difference in comparison with AN 200

ISSN: 2050-6511