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Table 1 Paw latency period on hot plate test in the experimental groups (n= 8 in each group)

From: N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test

  Control APAP NAC AN 200 AN 400 AN 600 Effect size CI (95%)
Baseline 9.83 ±1.8 8.27 ±1.1 9.2 ±1.6 8.48 ±1.18 8.6±1.5 8.88±1.89 0.01 0.08–0.15
30 min 9.13±1.92 12.37±2.01a 10.50±2.24b 12.76±1.77ac 14.46±1.69ac 16.40±1.53abcd 0.65 0.55–0.78
60 min 9.18±1.71 14.58±1.68a 13.11±1.83a 14.59±1.57a 17.45±2.36abcd 18.79±3.35abcd 0.70 0.67–0.75
90 min 9.04±1.67 16.95±1.91a 14.20±2.29a 17.2±2.26a 19.49±2.85abc 22.91±5.19abcd 0.71 0.67–0.79
  1. The analgesic effect of acetaminophen (APAP), N-acetylcysteine (NAC) and simultaneous feeding of acetaminophen (300 mg/kg) with the dosage of 200–600 mg/kg of NAC and comparing that with the control group in rats. There were 8 Sprague-Dawley rats in each group. Delay periods in the all groups were analyzed through the one-way ANOVA test followed by the Bonferroni post hoc test. The data have been reported by mean± standard deviation
  2. asignificant difference with the control group
  3. bsignificant difference in comparison with APAP
  4. csignificant difference in comparison with NAC
  5. dsignificant difference in comparison with AN 200