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Table 2 Summary of reported adverse events by dose

From: Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

 2-Hydroxybenzylamine acetate doseTotal (n = 18)
Placebo (n = 6)500 mg (n = 6)750 mg (n = 6)
Any event, n (%)4 (67)6 (100)4 (67)14 (78)
Headache2 (33)2 (33)2 (33)6 (33)
GI distress (nausea, bloating, constipation)2 (33)1 (17)0 (0)3 (17)
Rash/itching1 (17)1 (17)1 (17)3 (17)
Urine odor0 (0)2 (33)0 (0)2 (11)
Dry mouth1 (17)1 (17)0 (0)2 (11)
Nasal congestion0 (0)2 (33)0 (0)2 (11)
Lethargy/sleepiness0 (0)1 (17)1 (17)2 (11)
Hypertension0 (0)1 (17)0 (0)1 (6)
Eye irritation0 (0)1 (17)0 (0)1 (6)