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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells

Fig. 1

Concentration-dependent inhibitory effects of bupivacaine, ropivacaine, and lidocaine on SK2 currents. a The SK2 current was inhibited by local anesthetics and apamin in an SK2 cell. b, c, and d Dose-dependent effects of bupivacaine in terms of inhibiting SK2 currents (0 mV) were fitted to the Hill equation to obtain the IC50 value of bupivacaine, ropivacaine, and lidocaine, respectively. The equation was Y = Bottom + (Top − Bottom)/(1 + 10((LogIC50-X)*HillSlope)). The pipette solution contained 1μM free calcium

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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