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Table 2 Effect of treatment with alamandine on inflammatory cytokines and NF-kB in DOX-treated rats

From: Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats

  Sham Control Ala Dox Dox + Ala
TGF-β in Urine
(pg/mg creatinine)
16.48 ± 5.69 17.20 ± 5.50 23.34 ± 8.44 79.89 ± 15.78***††† 56.22 ± 13.33***##†††
TGF-β in Kidney
(pg/mg protein)
142.7 ± 45.99 135.9 ± 22.56 179.1 ± 67.20 534.4 ± 99.90***††† 404.4 ± 77.23***##†††
Serum IL-1훽 (pg/ml) 363.4 ± 99.9 350.0 ± 86.8 342.2 ± 89.99 552.1 ± 109.3**†† 453.9 ± 105.3
Serum IL-6 (pg/ml) 22.32 ± 5.53 20.10 ± 5.34 21.23 ± 6.56 47.46 ± 10.32***††† 34.98 ± 9.77**#††
Serum NF-kB (ng/ml) 6.5‎±‎2.1 6.3‎±‎1.9 6.4‎±‎1.9 10.2‎±‎2.2* 7.3‎±‎2.1
  1. Data are expressed as mean ± SD; n = 7 for each group
  2. P < 0.05, ‎†‎‎†P < 0. 01, ‎†‎‎†‎‎†P < 0.001 compared to the sham‎;‎
  3. *P < 0. 05, ‎**P < 0. 01, ***P < 0.001 compared to the control;
  4. #P < 0.05, ##P < 0. 01 compared to the DOX group