Table 2 Effect of treatment with alamandine on inflammatory cytokines and NF-kB in DOX-treated rats
From: Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats
Sham | Control | Ala | Dox | Dox + Ala | |
|---|---|---|---|---|---|
TGF-β in Urine (pg/mg creatinine) | 16.48 ± 5.69 | 17.20 ± 5.50 | 23.34 ± 8.44 | 79.89 ± 15.78***††† | 56.22 ± 13.33***##††† |
TGF-β in Kidney (pg/mg protein) | 142.7 ± 45.99 | 135.9 ± 22.56 | 179.1 ± 67.20 | 534.4 ± 99.90***††† | 404.4 ± 77.23***##††† |
Serum IL-1훽 (pg/ml) | 363.4 ± 99.9 | 350.0 ± 86.8 | 342.2 ± 89.99 | 552.1 ± 109.3**†† | 453.9 ± 105.3 |
Serum IL-6 (pg/ml) | 22.32 ± 5.53 | 20.10 ± 5.34 | 21.23 ± 6.56 | 47.46 ± 10.32***††† | 34.98 ± 9.77**#†† |
Serum NF-kB (ng/ml) | 6.5±2.1 | 6.3±1.9 | 6.4±1.9 | 10.2±2.2*† | 7.3±2.1 |