Factor | Parecoxib Group (N = 51) | Placebo Group (N = 54) | P value |
---|---|---|---|
Demographic and baseline | |||
Age, y | 69.9 ± 3.9 | 70.1 ± 4.2 | 0.79 |
Male, No. (%) | 41 (80.4) | 38 (70.4) | 0.23 |
BMI, kg/m2 | 23.6 ± 2.7 | 23.0 ± 3.1 | 0.33 |
ASA status, No. (%) | 0.66 | ||
I | 22 (43.1) | 21 (38.9) | |
II | 29 (56.9) | 33 (61.1) | |
History of diabetes, No. (%) | 3 (5.9) | 10 (18.5) | 0.05 |
History of hypertension, No. (%) | 24 (47.1) | 26 (48.1) | 0.91 |
HADS- anxiety score, point | 2.2 ± 1.7 | 2.7 ± 2.7 | 0.73 |
HADS- depression score, point | 1.4 ± 1.4 | 1.0 ± 1.8 | 0.03a |
Surgical characteristics | |||
TNM stage of hepatocellular carcinoma | 0.399 | ||
T1N0M0 | 18 (35.3) | 13 (24.1) | |
T2N0M0 | 22 (43.1) | 25 (46.3) | |
T3N0M0 | 11 (21.6) | 16 (29.6) | |
Duration of surgery, h | 2.5 ± 0.9 | 2.4 ± 1.1 | 0.43 |
Segment resected, No. (%) | 0.07 | ||
1 | 25 (49.0) | 25 (46.3) | |
2 | 18 (35.3) | 11 (20.4) | |
3 | 8 (15.7) | 18 (33.3) | |
Pringle manerver duration, min | 19.7 ± 12.4 | 18.9 ± 11.9 | 0.74 |
Intraoperative blood loss, mL | 245.5 ± 188.8 | 229.1 ± 182.2 | 0.65 |
Intraoperative urine output, mL | 277.5 ± 254.4 | 267.0 ± 233.9 | 0.83 |
Fluids volume (crystalloids, colloids), L | 2.1 ± 0.6 | 1.9 ± 0.6 | 0.18 |
Intraoperative fentanyl infusion, ug/kg | 3.7 ± 0.7 | 3.6 ± 0.7 | 0.44 |