Skip to main content

Table 5 Statistical Analysis of accumulation ratio basis PK parameters of Metformin

From: Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

PK Parameter RE 500 mg + Metformin
(Day 13/Day-1)
RE 750 mg + Metformin
(Day 13/Day-1)
AUC(0-tau)
(hr.ng/ml)
1.03 (0.97, 1.09) 1.01 (0.88–1.16)
Cmax
(ng/ml)
0.98 (0.9, 1.08) 0.96 (0.84–1.10)
  1. PK = RE Remogliflozin Etabonate
  2. Values are point estimate (90% confidence interval) of the geometric least-square mean ratio, Day 13 versus Day- 1