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Table 5 Statistical Analysis of accumulation ratio basis PK parameters of Metformin

From: Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

PK Parameter

RE 500 mg + Metformin

(Day 13/Day-1)

RE 750 mg + Metformin

(Day 13/Day-1)

AUC(0-tau)

(hr.ng/ml)

1.03 (0.97, 1.09)

1.01 (0.88–1.16)

Cmax

(ng/ml)

0.98 (0.9, 1.08)

0.96 (0.84–1.10)

  1. PK = RE Remogliflozin Etabonate
  2. Values are point estimate (90% confidence interval) of the geometric least-square mean ratio, Day 13 versus Day- 1
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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